Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.48 |
| ▸ | MAPT | P10636 | 8/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.48 |
| ▸ | HPGD | P15428 | 5/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.48 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | BLM | P54132 | 4/20 | 0.43 |
| ▸ | RECQL | P46063 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | ALPL | P05186 | 1/20 | 0.43 |
| ▸ | ALPI | P09923 | 1/20 | 0.43 |
| ▸ | ALPG | P10696 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 4/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7487588 | 0.90 | MEN1 (0.55) | MEN1MAPTKMT2AALDH1A1HPGD | |
| SCHEMBL7035542 | 0.87 | MEN1 (0.52) | MEN1MAPTKMT2AALDH1A1HPGD | |
| SCHEMBL4537409 | 0.82 | TEAD3 (0.43) | MEN1MAPTKMT2AALDH1A1HPGD | |
| SCHEMBL7487255 | 0.82 | MAPT (0.63) | MEN1MAPTKMT2AALDH1A1HPGD | |
| SCHEMBL7035556 | 0.80 | MEN1 (0.60) | MEN1MAPTKMT2AALDH1A1HPGD | |
| SCHEMBL2203358 | 0.80 | MEN1 (0.60) | MEN1MAPTKMT2AALDH1A1HPGD | |
| SCHEMBL18902663 | 0.79 | MEN1 (0.51) | MEN1MAPTKMT2AALDH1A1HPGD | |
| SCHEMBL16166235 | 0.79 | ALDH1A1 (0.51) | MEN1MAPTKMT2AALDH1A1HPGD | |
| SCHEMBL16166500 | 0.79 | MEN1 (0.62) | MEN1MAPTKMT2AALDH1A1HPGD | |
| SCHEMBL10080321 | 0.79 | APOBEC3A (0.32) | MEN1MAPTKMT2AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012062229-A1 | A METHOD OF MANUFACTURING (-)-L-(3-HYDROXYPROPYL)-5-[(2R)-2-({2,2,2-TRIFLUOROETHOXY)- PHENOXYETHYL}AMINO)PROPYL]-2,3-DIHYDRO-LH-INDOLE-7-CARBOXAMIDE | ZENTIVA, K.S. (CZ) | 2012-05-18 | — | — | WO | disclosed |