Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.41 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5042470 | 0.84 | HCAR3 (0.46) | SIRT6HCAR3KDM4ETSHRTDP1 | |
| SCHEMBL5133491 | 0.78 | HCAR3 (0.43) | SIRT6HCAR3KDM4ETSHRTDP1 | |
| SCHEMBL5133216 | 0.77 | NNMT (0.41) | HCAR3KDM4EMEN1ALDH1A1CYP1A2 | |
| SCHEMBL30482977 | 0.76 | SIRT6 (0.46) | SIRT6HCAR3KDM4ETSHRTDP1 | |
| SCHEMBL6469274 | 0.76 | MAPT (0.36) | HCAR3KDM4EMEN1ALDH1A1LMNA | |
| SCHEMBL5134193 | 0.76 | TSHR (0.44) | SIRT6HCAR3KDM4ETSHRTDP1 | |
| SCHEMBL5133377 | 0.75 | S1PR1 (0.46) | HCAR3CRHR1 | |
| SCHEMBL30874243 | 0.72 | SIRT6 (0.52) | SIRT6HCAR3KDM4ETSHRALDH1A1 | |
| SCHEMBL2222631 | 0.72 | SIRT6 (0.52) | SIRT6HCAR3KDM4ETSHRALDH1A1 | |
| SCHEMBL6470817 | 0.72 | CNR1 (0.35) | HCAR3KDM4ETSHRMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050107381-A1 | 6-membered heteroaryl compounds for the treatment of neurodegenerative disorders | PFIZER, INC. | 2005-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107381-A1 | 6-membered heteroaryl compounds for the treatment of neurodegenerative disorders | APP, BACE1, SNCA | SIRT6 750/4885HCAR3 748/4885KDM4E 3151/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.