Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR174 | Q9BXC1 | 14/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ABCC9 | O60706 | 2/20 | 0.42 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.42 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.42 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7621994 | 0.85 | GPR174 (0.59) | GPR174KMT2AMAPTTDP1ABCC9 | |
| SCHEMBL7233074 | 0.85 | ABCC9 (0.50) | GPR174KMT2AABCC9ABCC8KCNJ11 | |
| SCHEMBL7629544 | 0.84 | ABCC9 (0.46) | GPR174KMT2AGAAABCC9ABCC8 | |
| SCHEMBL7235689 | 0.84 | ABCC9 (0.47) | GPR174KMT2AABCC9ABCC8KCNJ11 | |
| SCHEMBL7236941 | 0.84 | ABCC9 (0.49) | GPR174KMT2AABCC9ABCC8KCNJ11 | |
| SCHEMBL7630640 | 0.81 | ABCC9 (0.45) | GPR174KMT2AMAPTTDP1ABCC9 | |
| SCHEMBL6432141 | 0.81 | ABCC9 (0.47) | GPR174KMT2AMAPTTDP1ABCC9 | |
| SCHEMBL6435908 | 0.80 | GPR174 (0.56) | GPR174GAAABCC9ABCC8KCNJ11 | |
| SCHEMBL6432586 | 0.79 | ABCC9 (0.61) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL7234562 | 0.78 | KMT2A (0.47) | GPR174KMT2AGAAMAPTABCC9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1194429-B1 | POTASSIUM CHANNEL OPENERS | ABBOTT LAB (US) | 2005-03-30 | — | — | EP | claimed |
| EP-1194429-A1 | POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2002-04-10 | — | — | EP | claimed |
| WO-2000078768-A1 | POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2000-12-28 | — | — | WO | claimed |
| EP-1194429-A1 | POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2002-04-10 | — | — | EP | disclosed |
| WO-2000078768-A1 | POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2000-12-28 | — | — | WO | disclosed |