Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | DRD2 | P14416 | 4/20 | 0.49 |
| ▸ | THRB | P10828 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6606492 | 0.86 | LMNA (0.52) | MAPTDRD2THRBLMNAMMP13 | |
| SCHEMBL6609494 | 0.84 | LMNA (0.51) | NPC1RAB9AMAPTDRD2THRB | |
| SCHEMBL6605355 | 0.83 | LMNA (0.51) | NPC1RAB9AMAPTDRD2THRB | |
| SCHEMBL6607141 | 0.81 | MMP13 (0.53) | NPC1MAPTDRD2THRBLMNA | |
| SCHEMBL6512902 | 0.81 | ALDH1A1 (0.53) | MAPTDRD2MEN1KMT2APOLB | |
| SCHEMBL6607569 | 0.81 | LMNA (0.48) | NPC1RAB9AMAPTDRD2THRB | |
| SCHEMBL6512442 | 0.80 | LMNA (0.49) | RAB9AMAPTDRD2THRBLMNA | |
| SCHEMBL6607095 | 0.80 | LMNA (0.49) | NPC1RAB9AMAPTDRD2THRB | |
| SCHEMBL6605189 | 0.79 | MMP13 (0.60) | MAPTTHRBLMNAKMT2AMMP13 | |
| SCHEMBL7088214 | 0.79 | LMNA (0.48) | NPC1RAB9AMAPTDRD2THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1530475-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING AN ALLOSTERIC CARBOXYLIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 AND A SELECTIVE INHIBITOR OF CYCLOOXYGENASE-2 | Warner-Lambert Company LLC (US) | 2005-05-18 | — | — | EP | disclosed |
| WO-2004006931-A2 | PHARMACEUTICAL COMPOSTIONS COMPRISING AN ALLOSTERIC CARBOXYLIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 AND A SELECTIVE INHIBITOR OF CYCLOOXYGENASE-2 | WARNER-LAMBERT COMPANY LLC (US) | 2004-01-22 | — | — | WO | disclosed |