Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 3/20 | 0.53 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.52 |
| ▸ | SELE | P16581 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | CDK7 | P50613 | 1/20 | 0.47 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.44 |
| ▸ | ACR | P10323 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6470755 | 0.86 | CYP3A4 (0.44) | CDK8ICAM1SELEUSP2KMT2A | |
| SCHEMBL6470823 | 0.81 | CDK8 (0.52) | CDK8KMT2AL3MBTL1ALDH1A1POLB | |
| SCHEMBL8721009 | 0.79 | MAPT (0.55) | ICAM1SELEUSP2KMT2AL3MBTL1 | |
| SCHEMBL5042253 | 0.78 | LYN (0.54) | CDK8KMT2AL3MBTL1ALDH1A1GAA | |
| SCHEMBL5524087 | 0.77 | L3MBTL1 (0.62) | ICAM1SELEUSP2KMT2AL3MBTL1 | |
| SCHEMBL27202487 | 0.77 | USP2 (0.82) | CDK8ICAM1SELEUSP2KMT2A | |
| SCHEMBL29006543 | 0.77 | ICAM1 (0.52) | CDK8ICAM1SELEUSP2KMT2A | |
| SCHEMBL30254925 | 0.77 | ICAM1 (0.52) | CDK8ICAM1SELEUSP2KMT2A | |
| SCHEMBL11412080 | 0.77 | CDK8 (0.55) | CDK8L3MBTL1ALDH1A1POLBGAA | |
| SCHEMBL9798371 | 0.76 | LTA4H (0.54) | L3MBTL1ALDH1A1POLBKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050107381-A1 | 6-membered heteroaryl compounds for the treatment of neurodegenerative disorders | PFIZER, INC. | 2005-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107381-A1 | 6-membered heteroaryl compounds for the treatment of neurodegenerative disorders | APP, BACE1, SNCA | CDK8 4238/4885ICAM1 3871/4885SELE 4340/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.