Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 2/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | TTBK1 | Q5TCY1 | 2/20 | 0.46 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.46 |
| ▸ | CDK7 | P50613 | 1/20 | 0.46 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6470759 | 0.84 | CYP3A4 (0.49) | CDK8L3MBTL1ALDH1A1POLBMAPT | |
| SCHEMBL9798371 | 0.82 | LTA4H (0.54) | ADORA2AL3MBTL1ALDH1A1POLBMAPT | |
| SCHEMBL6470820 | 0.81 | CDK8 (0.53) | CDK8L3MBTL1ALDH1A1POLBMAPT | |
| SCHEMBL23217081 | 0.80 | SCN9A (0.49) | CDK8L3MBTL1ALDH1A1MAPTLMNA | |
| SCHEMBL6153537 | 0.80 | TSHR (0.68) | ADORA2AL3MBTL1ALDH1A1POLBMAPT | |
| SCHEMBL30539120 | 0.80 | TSHR (0.68) | ADORA2AL3MBTL1ALDH1A1POLBMAPT | |
| SCHEMBL22534762 | 0.79 | L3MBTL1 (0.50) | CDK8ADORA2AL3MBTL1ALDH1A1POLB | |
| SCHEMBL27579381 | 0.79 | LTA4H (0.59) | ADORA2AL3MBTL1ALDH1A1POLBMAPT | |
| SCHEMBL30341595 | 0.78 | CDK8 (0.50) | CDK8L3MBTL1ALDH1A1POLBTTBK1 | |
| SCHEMBL16539369 | 0.78 | CDK8 (0.50) | CDK8L3MBTL1ALDH1A1POLBTTBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050107381-A1 | 6-membered heteroaryl compounds for the treatment of neurodegenerative disorders | PFIZER, INC. | 2005-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107381-A1 | 6-membered heteroaryl compounds for the treatment of neurodegenerative disorders | APP, BACE1, SNCA | CDK8 4238/4885ADORA2A 173/4885L3MBTL1 391/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.