Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | XDH | P47989 | 2/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | VNN1 | O95497 | 1/20 | 0.36 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29953629 | 0.82 | KMT2A (0.50) | P4HTMKMT2AALDH1A1KDM4ESIRT6 | |
| SCHEMBL2645451 | 0.82 | KMT2A (0.50) | P4HTMKMT2AALDH1A1KDM4ESIRT6 | |
| SCHEMBL5037214 | 0.78 | P4HTM (0.58) | P4HTMKMT2AALDH1A1KDM4ESIRT6 | |
| SCHEMBL14313758 | 0.77 | KMT2A (0.49) | P4HTMKMT2AALDH1A1SIRT6NAMPT | |
| SCHEMBL19304056 | 0.75 | ALDH1A1 (0.47) | P4HTMKMT2AALDH1A1KDM4EMAPT | |
| SCHEMBL2760887 | 0.75 | KMT2A (0.47) | P4HTMKMT2ASIRT6NAMPTVNN1 | |
| SCHEMBL6470827 | 0.74 | ALDH1A1 (0.45) | ALDH1A1KDM4EMAPTXDHTRPA1 | |
| SCHEMBL16379657 | 0.74 | ALDH1A1 (0.45) | ALDH1A1KDM4EMAPTXDHTRPA1 | |
| SCHEMBL10959192 | 0.74 | ALDH1A1 (0.59) | KMT2AALDH1A1KDM4EMAPTXDH | |
| SCHEMBL28404616 | 0.72 | KMT2A (0.57) | P4HTMKMT2ASIRT6NAMPTVNN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050107381-A1 | 6-membered heteroaryl compounds for the treatment of neurodegenerative disorders | PFIZER, INC. | 2005-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107381-A1 | 6-membered heteroaryl compounds for the treatment of neurodegenerative disorders | APP, BACE1, SNCA | P4HTM 3028/4885KMT2A 2085/4885ALDH1A1 2820/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.