Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 3/20 | 0.41 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | F13A1 | P00488 | 1/20 | 0.37 |
| ▸ | TGM1 | P22735 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6468940 | 0.92 | TDP1 (0.49) | MAPTTDP1PKMVCAM1POLB | |
| SCHEMBL3661467 | 0.76 | KMT2A (0.41) | MAPTPKMKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL6468791 | 0.73 | TDP1 (0.46) | MAPTTDP1PKMPOLBKMT2A | |
| SCHEMBL3974928 | 0.73 | SMN1; SMN2 (0.47) | MAPTTDP1POLBKMT2AMEN1 | |
| SCHEMBL11573932 | 0.72 | MAPT (0.63) | MAPTTDP1VCAM1KMT2AMEN1 | |
| SCHEMBL1807309 | 0.70 | TDP1 (0.62) | MAPTTDP1PKMKMT2AMEN1 | |
| SCHEMBL27816041 | 0.69 | KMT2A (0.63) | PKMVCAM1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL4158554 | 0.69 | KMT2A (0.70) | PKMKMT2AMEN1SMN1; SMN2CA2 | |
| SCHEMBL370668 | 0.69 | KMT2A (0.70) | PKMKMT2AMEN1SMN1; SMN2CA2 | |
| SCHEMBL11576923 | 0.68 | TDP1 (0.59) | MAPTTDP1VCAM1SMN1; SMN2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005049593-A2 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | ABBOTT LABORATORIES (US) | 2005-06-02 | — | — | WO | disclosed |