Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | F2 | P00734 | 2/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.39 |
| ▸ | BDKRB1 | P46663 | 2/20 | 0.39 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7694792 | 0.79 | F2 (0.47) | ALDH1A1MEN1KMT2ACA2CA9 | |
| SCHEMBL30678498 | 0.78 | F2 (0.45) | ALDH1A1MEN1KMT2ACA2CA9 | |
| SCHEMBL1548597 | 0.75 | FBP1 (0.45) | ALDH1A1MEN1KMT2ACA2CA9 | |
| SCHEMBL1807309 | 0.74 | TDP1 (0.62) | SMN1; SMN2ALDH1A1MEN1KMT2ACA2 | |
| SCHEMBL28297463 | 0.73 | HTR6 (0.42) | CA2HTR2AHTR2CHTR2B | |
| SCHEMBL6470839 | 0.73 | MAPT (0.45) | SMN1; SMN2ALDH1A1MEN1KMT2ACA2 | |
| SCHEMBL29052405 | 0.72 | KMT2A (0.44) | ALDH1A1MEN1KMT2ACA2CA9 | |
| SCHEMBL31437144 | 0.72 | KMT2A (0.44) | ALDH1A1MEN1KMT2ACA2CA9 | |
| SCHEMBL4690711 | 0.72 | KMT2A (0.48) | ALDH1A1MEN1KMT2ACA2CA9 | |
| SCHEMBL6468940 | 0.72 | TDP1 (0.49) | SMN1; SMN2ALDH1A1MEN1KMT2ACA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1907385-A4 | COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2009-05-06 | — | — | EP | disclosed |
| EP-1907385-A2 | COMPOUNDS | SmithKline Beecham Corporation (US) | 2008-04-09 | — | — | EP | disclosed |
| WO-2007018941-A2 | PYRIMIDYL-THIOPHENE DERIVATIVES | SMITHKLINE BEECHAM CORPORATION (US) | 2007-02-15 | — | — | WO | disclosed |