Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | CKS1B | P61024 | 1/20 | 0.32 |
| ▸ | SKP1 | P63208 | 1/20 | 0.32 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL989173 | 0.86 | TTK (0.37) | USP30CKS1BSKP1SKP2GPR119 | |
| SCHEMBL2031522 | 0.83 | SYK (0.38) | SYKPDPK1USP30GPR119SSTR4 | |
| SCHEMBL2654838 | 0.81 | RAB9A (0.47) | SYKPDPK1USP30SSTR4ALDH1A1 | |
| SCHEMBL29854904 | 0.81 | RAB9A (0.47) | SYKPDPK1USP30SSTR4ALDH1A1 | |
| SCHEMBL6018932 | 0.81 | SYK (0.37) | SYKPDPK1USP30GPR119SSTR4 | |
| SCHEMBL18211758 | 0.80 | HDAC1 (0.38) | SYKPDPK1ALDH1A1 | |
| SCHEMBL1770925 | 0.80 | HCAR3 (0.50) | ALDH1A1 | |
| SCHEMBL6451691 | 0.79 | KDM4E (0.36) | SYKPDPK1USP30SSTR4ALDH1A1 | |
| SCHEMBL12742316 | 0.79 | SYK (0.40) | SYKPDPK1ALDH1A1 | |
| SCHEMBL1770546 | 0.79 | GAA (0.36) | SYKPDPK1USP30GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578418-A2 | USE OF SUBSTITUTED 2,5-DIAMIDOINDOLES FOR THE TREATMENT OF UROLOGICAL DISEASES | Bayer HealthCare AG (DE) | 2005-09-28 | — | — | EP | disclosed |
| WO-2004056768-A2 | USE OF SUBSTITUTED 2,5-DIAMIDOINDOLES FOR THE TREATMENT OF UROLOGICAL DISEASES | BAYER HEALTHCARE AG (DE) | 2004-07-08 | — | — | WO | disclosed |