Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 1/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | CKS1B | P61024 | 1/20 | 0.34 |
| ▸ | SKP1 | P63208 | 1/20 | 0.34 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.32 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.31 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.31 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.31 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6471305 | 0.86 | SYK (0.35) | CKS1BSKP1SKP2GPR119ALDH1A1 | |
| SCHEMBL20037705 | 0.83 | TTK (0.39) | TTKPAX8CKS1BSKP1SKP2 | |
| SCHEMBL1181429 | 0.82 | GBA1 (0.42) | TTKPAX8GPR119BRD4ALDH1A1 | |
| SCHEMBL11968939 | 0.82 | GABRG2 (0.38) | TTKPAX8CKS1BSKP1SKP2 | |
| SCHEMBL56808 | 0.82 | TTK (0.37) | TTKPAX8CKS1BSKP1SKP2 | |
| SCHEMBL29827507 | 0.82 | GBA1 (0.42) | TTKPAX8GPR119BRD4ALDH1A1 | |
| SCHEMBL691501 | 0.81 | HCAR3 (0.51) | PAX8GPR119ALDH1A1HCAR3 | |
| SCHEMBL2068743 | 0.79 | CXCR2 (0.38) | TTKPAX8CKS1BSKP1SKP2 | |
| SCHEMBL692389 | 0.79 | HCAR3 (0.38) | TTKPAX8CKS1BSKP1SKP2 | |
| SCHEMBL26921931 | 0.79 | PAX8 (0.40) | TTKPAX8CKS1BSKP1SKP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451802-A1 | PYRIMIDINYL AND 1,3,5-TRIAZINYL BENZIMIDAZOLES AND THEIR USE IN CANCER THERAPY | Pathway Therapeutics, Inc. (US) | 2012-05-16 | — | — | EP | disclosed |
| WO-2011005119-A1 | PYRIMIDINYL AND 1,3,5-TRIAZINYL BENZIMIDAZOLES AND THEIR USE IN CANCER THERAPY | PATHWAY THERAPEUTICS LIMITED (NZ) | 2011-01-13 | — | — | WO | disclosed |