Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.40 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | AGXT | P21549 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6471124 | 0.93 | MAPK14 (0.38) | MAPK14PTGER1CNR1MAOBBRD4 | |
| SCHEMBL6473460 | 0.92 | MAPK14 (0.40) | MAPK14PTGER1CNR1MAOBBRD4 | |
| SCHEMBL6471360 | 0.88 | MAPK14 (0.44) | MAPK14PTGER1MAOBBRD4CYP1A1 | |
| SCHEMBL6471156 | 0.83 | MAPK14 (0.41) | MAPK14PTGER1MAOBGSK3BBACE1 | |
| SCHEMBL6471273 | 0.79 | MAPK14 (0.44) | MAPK14MAOBGSK3BBACE1 | |
| SCHEMBL6470956 | 0.77 | MAPK14 (0.44) | MAPK14MAOB | |
| SCHEMBL6533063 | 0.76 | MAPK14 (0.42) | MAPK14MAOBBRD4 | |
| SCHEMBL6470939 | 0.76 | MAPK14 (0.41) | MAPK14MAOBIDO1 | |
| SCHEMBL6473625 | 0.75 | HTR2A (0.38) | MAPK14PTGER1MAOB | |
| SCHEMBL6471570 | 0.74 | KMT2A (0.39) | MAPK14CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005018557-A2 | SUBSTITUTED PYRIDINONES | PHARMACIA CORPORATION (US) | 2005-03-03 | — | — | WO | disclosed |
| EP-1490064-A1 | SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE | Pharmacia Corporation (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003068230-A1 | SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE | PHARMACIA CORPORATION (US) | 2003-08-21 | — | — | WO | disclosed |