Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 10/20 | 0.38 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6472250 | 0.93 | MAPK14 (0.40) | MAPK14PTGER1MAOBCNR1BRD4 | |
| SCHEMBL6473460 | 0.87 | MAPK14 (0.40) | MAPK14PTGER1MAOBCNR1BRD4 | |
| SCHEMBL6471360 | 0.82 | MAPK14 (0.44) | MAPK14PTGER1MAOBBRD4CYP1A1 | |
| SCHEMBL6471156 | 0.79 | MAPK14 (0.41) | MAPK14PTGER1MAOBGSK3BBACE1 | |
| SCHEMBL6471273 | 0.75 | MAPK14 (0.44) | MAPK14MAOBGSK3BBACE1 | |
| SCHEMBL6470956 | 0.73 | MAPK14 (0.44) | MAPK14MAOB | |
| SCHEMBL6533063 | 0.73 | MAPK14 (0.42) | MAPK14MAOBBRD4 | |
| SCHEMBL6470939 | 0.72 | MAPK14 (0.41) | MAPK14MAOB | |
| SCHEMBL6470962 | 0.72 | MAOB (0.43) | MAPK14MAOB | |
| SCHEMBL6473625 | 0.71 | HTR2A (0.38) | MAPK14PTGER1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005011697-A2 | SULFONAMIDE DERIVATIVES WITH ACTIVITY ON PROTEIN KINASE A AND B | ASTEX THERAPEUTICS LIMITED (GB) | 2005-02-10 | — | — | WO | disclosed |