Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 5/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.47 |
| ▸ | AKR1C1 | Q04828 | 4/20 | 0.47 |
| ▸ | PPARG | P37231 | 3/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6472251 | 1.00 | AKR1C3 (0.47) | AKR1C3AKR1C2AKR1C1PPARGPTGS2 | |
| SCHEMBL8428502 | 0.86 | PTGS2 (0.38) | AKR1C3AKR1C2AKR1C1PPARGPTGS2 | |
| SCHEMBL8797000 | 0.85 | AKR1C3 (0.45) | AKR1C3AKR1C2AKR1C1PTGS2PTGS1 | |
| SCHEMBL2219869 | 0.83 | AKR1C3 (0.57) | AKR1C3AKR1C2AKR1C1PTGS2TDP1 | |
| SCHEMBL8521003 | 0.83 | PTGS2 (0.45) | AKR1C3AKR1C2AKR1C1PTGS2 | |
| SCHEMBL8506321 | 0.83 | PTGS2 (0.38) | AKR1C3AKR1C2AKR1C1PPARGPTGS2 | |
| SCHEMBL2223120 | 0.83 | PTGS2 (0.38) | AKR1C3AKR1C2AKR1C1PPARGPTGS2 | |
| SCHEMBL5138929 | 0.81 | AKR1C3 (0.43) | AKR1C3AKR1C2AKR1C1PTGS2TDP1 | |
| SCHEMBL8430248 | 0.75 | CES2 (0.35) | CYP1A2MAPTPOLBALDH1A1MEN1 | |
| SCHEMBL7840253 | 0.73 | AKR1C3 (0.56) | AKR1C3AKR1C2AKR1C1PPARGPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2882426-A1 | METHODS AND PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF CYSTIC FIBROSIS | Institut National de la Santé et de la Recherche Médicale (INSERM) (FR) | 2015-06-17 | — | — | EP | disclosed |
| WO-2014026959-A1 | METHODS AND PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF CYSTIC FIBROSIS | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2014-02-20 | — | — | WO | disclosed |
| WO-2005068411-A1 | PROCESS FOR THE PREPARATION OF 6-FLUORO-2-METHYL-1-INDANONE | ZAMBON GROUP S.P.A. (IT) | 2005-07-28 | — | — | WO | disclosed |
| WO-1998013073-A9 | METHODS OF ENHANCING THE THERAPEUTIC ACTIVITY OF NSAIDs AND COMPOSITIONS OF ZWITTERIONIC PHOSPHOLIPIDS USEFUL THEREIN | — | 1998-08-06 | — | — | WO | disclosed |
| EP-0805684-A4 | METHODS OF ENHANCING THE THERAPEUTIC ACTIVITY OF NSAIDS AND COMPOSITIONS OF ZWITTERIONIC PHOSPHOLIPIDS USEFUL THEREIN | UNIV TEXAS (US) | 1998-08-05 | — | — | EP | disclosed |
| EP-0805684-A2 | METHODS OF ENHANCING THE THERAPEUTIC ACTIVITY OF NSAIDS AND COMPOSITIONS OF ZWITTERIONIC PHOSPHOLIPIDS USEFUL THEREIN | THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1997-11-12 | — | — | EP | disclosed |
| WO-1996022780-A1 | METHODS OF ENHANCING THE THERAPEUTIC ACTIVITY OF NSAIDS AND COMPOSITIONS OF ZWITTERIONIC PHOSPHOLIPIDS USEFUL THEREIN | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 1996-08-01 | — | — | WO | disclosed |
| EP-0206241-A1 | Process for the preparation of cis-5-fluoro-2-methyl-1-(4-methylthiobenzylidene)-indene-3-acetic acid | ZAMBON S.p.A. (IT) | 1986-12-30 | — | — | EP | disclosed |