Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.37 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | EDNRA | P25101 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8506321 | 1.00 | PTGS2 (0.38) | PTGS2AKR1C3AKR1C2AKR1C1ALDH1A1 | |
| SCHEMBL15572432 | 0.90 | PTGS2 (0.34) | PTGS2AKR1C3AKR1C2AKR1C1ALDH1A1 | |
| SCHEMBL15571625 | 0.89 | AKR1C3 (0.37) | PTGS2AKR1C3AKR1C2AKR1C1MAOA | |
| SCHEMBL15570939 | 0.89 | PTGS2 (0.37) | PTGS2AKR1C3AKR1C2AKR1C1MAOA | |
| SCHEMBL2221809 | 0.87 | AKR1C3 (0.37) | PTGS2AKR1C3AKR1C2AKR1C1ALDH1A1 | |
| SCHEMBL15572558 | 0.87 | AKR1C3 (0.40) | PTGS2AKR1C3 | |
| SCHEMBL15570465 | 0.85 | AKR1C3 (0.39) | AKR1C3ALDH1A1MEN1KMT2AMAOB | |
| SCHEMBL8796929 | 0.85 | MAOA (0.34) | PTGS2AKR1C3ALDH1A1MEN1KMT2A | |
| SCHEMBL2223831 | 0.85 | PTGS2 (0.32) | PTGS2AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL8428502 | 0.84 | PTGS2 (0.38) | PTGS2AKR1C3AKR1C2AKR1C1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2882426-A1 | METHODS AND PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF CYSTIC FIBROSIS | Institut National de la Santé et de la Recherche Médicale (INSERM) (FR) | 2015-06-17 | — | — | EP | disclosed |
| WO-2014026959-A1 | METHODS AND PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF CYSTIC FIBROSIS | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2014-02-20 | — | — | WO | disclosed |
| WO-2011088474-A2 | SULINDAC AND SULINDAC DERIVATIVES AND THEIR USES RELATED TO INFECTION | Zirus, Inc. (US) | 2011-07-21 | — | — | WO | disclosed |
| WO-2005068411-A1 | PROCESS FOR THE PREPARATION OF 6-FLUORO-2-METHYL-1-INDANONE | ZAMBON GROUP S.P.A. (IT) | 2005-07-28 | — | — | WO | disclosed |