Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.54 |
| ▸ | STS | P08842 | 1/20 | 0.49 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4791995 | 0.88 | NAMPT (0.51) | KDM4EPKMGPR119STS | |
| SCHEMBL735207 | 0.84 | HPGD (0.54) | KDM4EPKMGPR119 | |
| SCHEMBL7990377 | 0.84 | GPR119 (0.59) | KDM4EPKMGPR119STS | |
| SCHEMBL31607832 | 0.81 | KDM4E (0.54) | KDM4EPKMGPR119STSLIMK2 | |
| Iodide SCHEMBL7495522 | 0.80 | KDM4E (0.52) | KDM4EPKMGPR119STSLIMK2 | |
| Iodide SCHEMBL4346071 | 0.78 | JAK2 (0.48) | KDM4EPKMGPR119STSTGFBR1 | |
| Iodide SCHEMBL4342693 | 0.78 | JAK2 (0.48) | KDM4EPKMGPR119STSTGFBR1 | |
| SCHEMBL3923737 | 0.78 | KDM4E (0.64) | KDM4EPKMGPR119STSMEN1 | |
| SCHEMBL8444749 | 0.78 | KDM4E (0.58) | KDM4EPKMGPR119STSLIMK2 | |
| SCHEMBL1912705 | 0.77 | KDM4E (0.62) | KDM4EPKMGPR119STSTGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567511-A1 | SUBSTITUTED PIPERAZINES, (1,4) DIASZEPINES, AND 2,5-DIAZABICYCLO (2.2.1) HEPTANES AS HISTAMINE H1 AND/OR H3 ANTAGONISTS OR HISTAMINE H3 REVERSE ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2005-08-31 | — | — | EP | disclosed |
| WO-2004035556-A1 | SUBSTITUTED PIPERAZINES, (1,4) DIASZEPINES, AND 2,5-DIAZABICYCLO (2.2.1) HEPTANES AS HISTAMINE H1 AND/OR H3 ANTAGONISTS OR HISTAMINE H3 REVERSE ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2004-04-29 | — | — | WO | disclosed |