Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | RORC | P51449 | 3/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | STS | P08842 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6473168 | 0.88 | KDM4E (0.58) | KDM4EPKMGPR119STS | |
| SCHEMBL3001141 | 0.83 | NR1H2 (0.58) | NAMPTKDM4EPKMRORCNR1H2 | |
| SCHEMBL10655540 | 0.80 | RORC (0.49) | NAMPTKDM4EPKMRORCGPR119 | |
| SCHEMBL17736150 | 0.77 | NAMPT (0.56) | NAMPTKDM4EPKMRORCGPR119 | |
| SCHEMBL7990377 | 0.76 | GPR119 (0.59) | KDM4EPKMGPR119STS | |
| Iodide SCHEMBL4342693 | 0.76 | JAK2 (0.48) | KDM4EPKMGPR119USP30JAK2 | |
| Iodide SCHEMBL4346071 | 0.76 | JAK2 (0.48) | KDM4EPKMGPR119USP30JAK2 | |
| SCHEMBL28341502 | 0.75 | NAMPT (0.54) | NAMPTKDM4EPKMRORCGPR119 | |
| SCHEMBL796329 | 0.75 | NAMPT (0.54) | NAMPTKDM4EPKMRORCGPR119 | |
| SCHEMBL27765760 | 0.74 | NAMPT (0.51) | NAMPTKDM4EPKMRORCGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004669-A1 | AZAHETEROCYCLYL DERIVATIVES OF ANDROSTANES AND ANDROSTENES AS MEDICAMENTS FOR CARDIOVASCULAR DISORDERS | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. (IT) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007118830-A1 | AZAHETEROCYCLYL DERIVATIVES OF ANDROSTANES AND ANDROSTENES AS MEDICAMENTS FOR CARDIOVASCULAR DISORDERS | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2007-10-25 | — | — | WO | disclosed |