Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 7/20 | 0.59 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | GLA | P06280 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | THPO | P40225 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | APEX1 | P27695 | 2/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.57 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.49 |
| ▸ | HRH2 | P25021 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | MIF | P14174 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26687866 | 0.81 | HRH3 (0.59) | HRH4HRH3ALDH1A1NFKB1MEN1 | |
| SCHEMBL11614874 | 0.81 | HRH3 (0.59) | HRH4HRH3ALDH1A1NFKB1MEN1 | |
| Hydrochloric Acid SCHEMBL11612123 | 0.80 | HRH4 (0.61) | HRH4HRH3ALDH1A1NFKB1MEN1 | |
| Hydrochloric Acid SCHEMBL11614746 | 0.80 | HRH4 (0.61) | HRH4HRH3ALDH1A1NFKB1MEN1 | |
| SCHEMBL6546327 | 0.76 | HRH4 (0.61) | HRH4HRH3ALDH1A1NFKB1MEN1 | |
| Histidine SCHEMBL6005501 | 0.75 | CYP3A4 (0.97) | HRH4HRH3ALDH1A1NFKB1MEN1 | |
| Histidine SCHEMBL28435851 | 0.75 | CYP3A4 (0.97) | HRH4HRH3ALDH1A1NFKB1MEN1 | |
| SCHEMBL3925179 | 0.75 | — | — | |
| SCHEMBL12328968 | 0.75 | — | — | |
| SCHEMBL13436837 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6960574-B2 | Antagonists of RF-amide neuropeptides | UNIVERSITY OF FLORIDA (US) | 2005-11-01 | — | — | US | disclosed |
| US-6797707-B2 | THERAPEUTIC TREATMENT OF OPIATE AND NICOTINE ADDICTION, DRUG DEPENDENCE, AND TOLERANCE; A POLYPEPTIDE DERIVATIVES HAVING N-TERMINAL 5-(DIMETHYLAMINO)-1-NAPHTHALENESULFONYL GROUP, C-TERMINAL ARGININE- AMIDE GROUP | UNIVERSITY OF FLORIDA | 2004-09-28 | — | — | US | disclosed |
| US-20040176340-A1 | Antagonists of RF-amide neuropeptides | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2004-09-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040176340-A1 | Antagonists of RF-amide neuropeptides | OPRL1, HCRTR2, OPRM1 | HRH4 71/4885HRH3 189/4885ALDH1A1 2528/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.