Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | ELANE | P08246 | 1/20 | 0.56 |
| ▸ | MAOB | P27338 | 3/20 | 0.52 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.51 |
| ▸ | TNKS2 | Q9H2K2 | 5/20 | 0.50 |
| ▸ | PARP1 | P09874 | 3/20 | 0.50 |
| ▸ | QTRT1 | Q9BXR0 | 1/20 | 0.50 |
| ▸ | TNKS | O95271 | 3/20 | 0.49 |
| ▸ | MGLL | Q99685 | 1/20 | 0.48 |
| ▸ | GUSB | P08236 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL15742407 | 0.81 | KDM4C (0.65) | KDM4CKMT2ARAB9AELANETNKS2 | |
| SCHEMBL6886533 | 0.80 | TNKS2 (0.56) | KDM4CKMT2ARAB9AMAOBHCAR2 | |
| SCHEMBL6004217 | 0.79 | TNKS2 (0.51) | KDM4CKMT2ARAB9AMAOBHCAR2 | |
| SCHEMBL28502323 | 0.79 | HCAR2 (0.53) | KDM4CKMT2ARAB9AMAOBHCAR2 | |
| SCHEMBL9118233 | 0.79 | GAA (0.53) | KDM4CRAB9AELANE | |
| SCHEMBL28503293 | 0.78 | PARP1 (0.59) | KDM4CKMT2ARAB9AMAOBHCAR2 | |
| SCHEMBL148952 | 0.77 | TNKS2 (0.61) | RAB9ATNKS2PARP1QTRT1TNKS | |
| SCHEMBL31070299 | 0.77 | TNKS2 (0.61) | RAB9ATNKS2PARP1QTRT1TNKS | |
| SCHEMBL27709478 | 0.77 | KMT2A (0.51) | KDM4CKMT2ARAB9AMAOBTNKS2 | |
| Hydrochloric Acid SCHEMBL15709417 | 0.76 | TNKS2 (0.59) | RAB9ATNKS2PARP1QTRT1TNKS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578755-A1 | PHOSPHONOOXY QUINAZOLINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | AstraZeneca AB (SE) | 2005-09-28 | — | — | EP | disclosed |
| WO-2004058781-A1 | PHOSPHONOOXY QUINAZOLINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ASTRAZENECA AB (SE) | 2004-07-15 | — | — | WO | disclosed |