Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YAP1 | P46937 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PSMB11 | A5LHX3 | 2/20 | 0.40 |
| ▸ | PSMA7 | O14818 | 2/20 | 0.40 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.40 |
| ▸ | PSMA1 | P25786 | 2/20 | 0.40 |
| ▸ | PSMA2 | P25787 | 2/20 | 0.40 |
| ▸ | PSMA3 | P25788 | 2/20 | 0.40 |
| ▸ | PSMA4 | P25789 | 2/20 | 0.40 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.40 |
| ▸ | PSMB9 | P28065 | 2/20 | 0.40 |
| ▸ | PSMA5 | P28066 | 2/20 | 0.40 |
| ▸ | PSMB4 | P28070 | 2/20 | 0.40 |
| ▸ | PSMB6 | P28072 | 2/20 | 0.40 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.40 |
| ▸ | PSMB10 | P40306 | 2/20 | 0.40 |
| ▸ | PSMB3 | P49720 | 2/20 | 0.40 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.40 |
| ▸ | PSMA6 | P60900 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6480778 | 0.92 | YAP1 (0.48) | YAP1L3MBTL1KDM4EPSMB11PSMA7 | |
| SCHEMBL6480791 | 0.91 | YAP1 (0.46) | YAP1PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL6478253 | 0.91 | L3MBTL1 (0.42) | YAP1L3MBTL1KDM4EPSMB11PSMA7 | |
| SCHEMBL6473339 | 0.89 | PSMB11 (0.44) | YAP1PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL6481324 | 0.88 | MAPK1 (0.44) | YAP1PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL7539927 | 0.88 | MAPK1 (0.44) | YAP1PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL6480951 | 0.87 | MAPK1 (0.47) | YAP1PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL6474215 | 0.86 | ITGB1 (0.46) | YAP1PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL6478996 | 0.85 | CACNA1B (0.47) | YAP1KDM4EPSMB11PSMA7PSMB1 | |
| SCHEMBL6474173 | 0.85 | PSMB11 (0.41) | YAP1L3MBTL1PSMB11PSMA7PSMB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6867192-B1 | Compounds useful in the treatment of inflammatory diseases | GLAXO GROUP LIMITED (GB) | 2005-03-15 | — | — | US | claimed |
| EP-1140837-B1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LTD (GB) | 2004-08-18 | — | — | EP | claimed |
| EP-1140837-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2001-10-10 | — | — | EP | claimed |
| WO-2000037444-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2000-06-29 | — | — | WO | claimed |
| US-6867192-B1 | Compounds useful in the treatment of inflammatory diseases | GLAXO GROUP LIMITED (GB) | 2005-03-15 | — | — | US | disclosed |
| EP-1486503-A1 | Derivatives of benzothiazine and benzothiadiazine, procedure for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2004-12-15 | — | — | EP | disclosed |
| EP-1140837-B1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LTD (GB) | 2004-08-18 | — | — | EP | disclosed |
| EP-1140837-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000037444-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2000-06-29 | — | — | WO | disclosed |