Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6481422 | 0.90 | ALDH1A1 (0.48) | SMN1; SMN2ALDH1A1LMNALPAR1THRB | |
| SCHEMBL6735652 | 0.82 | ALDH1A1 (0.46) | SMN1; SMN2ALDH1A1LMNALPAR1THRB | |
| SCHEMBL4431531 | 0.82 | SHMT2 (0.51) | SMN1; SMN2ALDH1A1LMNALPAR1THRB | |
| SCHEMBL4431529 | 0.82 | SHMT2 (0.51) | SMN1; SMN2ALDH1A1LMNALPAR1THRB | |
| SCHEMBL4435142 | 0.80 | MBTPS1 (0.47) | SMN1; SMN2ALDH1A1LMNALPAR1THRB | |
| SCHEMBL4435139 | 0.80 | MBTPS1 (0.47) | SMN1; SMN2ALDH1A1LMNALPAR1THRB | |
| SCHEMBL4423940 | 0.78 | ATM (0.48) | ALDH1A1LMNATHRB | |
| SCHEMBL4423941 | 0.78 | ATM (0.48) | ALDH1A1LMNATHRB | |
| SCHEMBL4421060 | 0.77 | ALDH1A1 (0.45) | SMN1; SMN2ALDH1A1LMNATHRBPOLB | |
| SCHEMBL4421059 | 0.77 | ALDH1A1 (0.45) | SMN1; SMN2ALDH1A1LMNATHRBPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6939888-B2 | 1-H-3-arylpirrolidine-2,4-dione derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 2005-09-06 | — | — | US | disclosed |
| US-20040019061-A1 | 1-H-3-arylpirrolidine-2,4-dione derivatives | FISCHER REINER (DE) | 2004-01-29 | — | — | US | disclosed |
| US-6472419-B1 | 1-H-3-aryl-pyrrolidine-2, 4-dione derivatives as pest-control agents | BAYER AKTIENGESELLSCHAFT (DE) | 2002-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040019061-A1 | 1-H-3-arylpirrolidine-2,4-dione derivatives | PRXL2A, DDT, CYP4B1 | SMN1; SMN2 3528/4885ALDH1A1 792/4885LMNA 2427/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.