⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6218904 | 0.78 | — | — | |
| SCHEMBL268874 | 0.76 | — | — | |
| SCHEMBL1397144 | 0.76 | CA1 (0.35) | — | |
| SCHEMBL5493506 | 0.76 | L3MBTL1 (0.32) | — | |
| SCHEMBL15431005 | 0.76 | L3MBTL1 (0.32) | — | |
| SCHEMBL1605045 | 0.73 | — | — | |
| SCHEMBL330404 | 0.73 | ALDH1A1 (0.32) | — | |
| SCHEMBL11360667 | 0.73 | CYP2C19 (0.37) | — | |
| SCHEMBL7620432 | 0.73 | — | — | |
| SCHEMBL15370335 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030119785-A1 | Vitronectin receptor antagonists, their preparation and use | HOECHST AKTIENGESELLSCHAFT AND GENENTECH INC. | 2003-06-26 | — | — | US | claimed |
| US-20030027807-A1 | Vitronectin receptor antagonists, their preparation and their use | GENENTECH, INC. AND HOECHST AKTIENGESELLSCHAFT | 2003-02-06 | — | — | US | claimed |
| US-20010011087-A1 | Vitronectin receptor antagonists, their preparation and their use | WEHNER VOLKMAR (DE) | 2001-08-02 | — | — | US | claimed |
| US-6218387-B1 | AS INHIBITORS OF BONE RESORPTION BY OSTEOCLASTS, FOR INHIBITING TUMOR GROWTH OR TUMOR METASTASIS, INHIBITING INFLAMMATION, OR FOR TREATMENT OR PROPHYLAXIS OF CARDIOVASCULAR DISEASES, NEUROPATHIES OR RETINOPATHIES | HOECHST AKTIENGESELLSCHAFT (DE) | 2001-04-17 | — | — | US | claimed |
| US-6207663-B1 | AS INHIBITORS OF BONE RESORPTION, TUMOR GROWTH, TUMOR METASTASIS, OR INFLAMMATION, OR FOR THE TREATMENT OR PROPHYLAXIS OF CARDIOVASCULAR DISORDERS, NEPHROPATHIES OR RETINOPATHIES | HOECHST ATKIENGESELLSCHAFT (DE) | 2001-03-27 | — | — | US | claimed |
| EP-0854145-A2 | Vitronectin receptor antagonists, their production and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-07-22 | — | — | EP | claimed |
| EP-0854140-A2 | Vitronectin receptor antagonists, their production and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-07-22 | — | — | EP | claimed |
| US-6867208-B2 | Vitronectin receptor antagonists, their preparation and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 2005-03-15 | — | — | US | disclosed |
| US-20030119785-A1 | Vitronectin receptor antagonists, their preparation and use | HOECHST AKTIENGESELLSCHAFT AND GENENTECH INC. | 2003-06-26 | — | — | US | disclosed |
| US-20030027807-A1 | Vitronectin receptor antagonists, their preparation and their use | GENENTECH, INC. AND HOECHST AKTIENGESELLSCHAFT | 2003-02-06 | — | — | US | disclosed |
| US-6482821-B2 | ANTIINFLAMMATORY AGENTS; ANTITUMOR AGENTS; CARDIOVACULAR DISORDERS | HOECHST AKTIENGELLSCHAFT (DE) | 2002-11-19 | — | — | US | disclosed |
| US-6387895-B1 | BONE DISORDERS; CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 2002-05-14 | — | — | US | disclosed |
| US-20010011087-A1 | Vitronectin receptor antagonists, their preparation and their use | WEHNER VOLKMAR (DE) | 2001-08-02 | — | — | US | disclosed |
| US-6218387-B1 | AS INHIBITORS OF BONE RESORPTION BY OSTEOCLASTS, FOR INHIBITING TUMOR GROWTH OR TUMOR METASTASIS, INHIBITING INFLAMMATION, OR FOR TREATMENT OR PROPHYLAXIS OF CARDIOVASCULAR DISEASES, NEUROPATHIES OR RETINOPATHIES | HOECHST AKTIENGESELLSCHAFT (DE) | 2001-04-17 | — | — | US | disclosed |
| US-6207663-B1 | AS INHIBITORS OF BONE RESORPTION, TUMOR GROWTH, TUMOR METASTASIS, OR INFLAMMATION, OR FOR THE TREATMENT OR PROPHYLAXIS OF CARDIOVASCULAR DISORDERS, NEPHROPATHIES OR RETINOPATHIES | HOECHST ATKIENGESELLSCHAFT (DE) | 2001-03-27 | — | — | US | disclosed |
| US-6011045-A | Vitronectin receptor antagonists, their preparation and their use | HOECHST AKTIENGESELLSCHAFT | 2000-01-04 | — | — | US | disclosed |
| US-5990145-A | Vitronectin receptor antagonists, their preparation and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-11-23 | — | — | US | disclosed |
| EP-0854145-A2 | Vitronectin receptor antagonists, their production and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-07-22 | — | — | EP | disclosed |
| EP-0854140-A2 | Vitronectin receptor antagonists, their production and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-07-22 | — | — | EP | disclosed |
| US-4448776-A | Method of using certain substituted aliphatic secondary amines or their salts for easing breathing | BUCHER KARL (CH) | 1984-05-15 | — | — | US | disclosed |