Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 3/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | FKBP1A | P62942 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6473445 | 0.99 | TBXAS1 (0.39) | TBXAS1PDE4DMAPK1GFERFKBP1A | |
| SCHEMBL8462850 | 0.88 | FKBP1A (0.40) | FKBP1A | |
| SCHEMBL3670538 | 0.81 | FKBP1A (0.49) | TBXAS1FKBP1AKDM4EALDH1A1POLB | |
| SCHEMBL3675773 | 0.80 | FKBP1A (0.46) | PDE4DFKBP1AKDM4EALDH1A1POLB | |
| SCHEMBL6471963 | 0.74 | FKBP1A (0.53) | FKBP1A | |
| SCHEMBL7173487 | 0.68 | GFER (0.41) | GFERFKBP1ACYP1A2CYP2C19 | |
| SCHEMBL7173479 | 0.68 | GFER (0.41) | GFERFKBP1ACYP1A2CYP2C19 | |
| SCHEMBL9549768 | 0.65 | TBXAS1 (0.46) | TBXAS1PDE4DALDH1A1CYP1A2 | |
| SCHEMBL18179929 | 0.64 | L3MBTL1 (0.45) | MAPK1KDM4EALDH1A1 | |
| SCHEMBL9549621 | 0.64 | TBXAS1 (0.44) | TBXAS1PDE4DALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0941113-A1 | METHODS AND COMPOSITIONS FOR STIMULATING NEURITE GROWTH USING COMPOUNDS WITH AFFINITY FOR FKBP12 IN COMBINATION WITH NEUROTROPHIC FACTORS | Vertex Pharmaceuticals Incorporated (US) | 1999-09-15 | — | — | EP | claimed |
| WO-1998020893-A1 | METHODS AND COMPOSITIONS FOR STIMULATING NEURITE GROWTH USING COMPOUNDS WITH AFFINITY FOR FKBP12 IN COMBINATION WITH NEUROTROPHIC FACTORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 1998-05-22 | — | — | WO | claimed |
| WO-2005007162-A1 | COMPOUNDS AUGMENTING THE ACTIVITY OF ANTIBACTERIAL AGENTS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2005-01-27 | — | — | WO | disclosed |