Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 2/20 | 0.58 |
| ▸ | ALOX5 | P09917 | 14/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.47 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6485915 | 1.00 | PTGES (0.58) | PTGESALOX5PTGS1PTGS2ALOX5AP | |
| SCHEMBL6476126 | 0.85 | ALOX5 (0.47) | PTGESALOX5PTGS1PTGS2 | |
| SCHEMBL6476634 | 0.81 | PTGS2 (0.51) | PTGESPTGS1PTGS2 | |
| SCHEMBL6476911 | 0.81 | PTGS2 (0.51) | PTGESPTGS1PTGS2 | |
| SCHEMBL6476339 | 0.79 | PTGES (0.65) | PTGESALOX5PTGS1PTGS2ALOX5AP | |
| SCHEMBL6484148 | 0.77 | PTGES (0.58) | PTGESALOX5PTGS1 | |
| SCHEMBL6486937 | 0.77 | PTGES (0.58) | PTGESALOX5PTGS1 | |
| SCHEMBL1394083 | 0.77 | PTGES (0.58) | PTGESALOX5PTGS1PTGS2ALOX5AP | |
| SCHEMBL6483250 | 0.77 | PTGES (0.58) | PTGESALOX5PTGS1 | |
| SCHEMBL6485138 | 0.77 | PTGES (0.58) | PTGESALOX5PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6936632-B2 | Fused pyrrole compounds, pharmaceutical agents containing the same, and the use thereof | MERCKLE GMBH (DE) | 2005-08-30 | — | — | US | disclosed |
| US-20040122002-A1 | Fused pyrrole compounds, pharmaceutical agents containing the same, and the use thereof | MERCKLE GMBH (DE) | 2004-06-24 | — | — | US | disclosed |
| EP-1246825-B1 | FUSED PYRROLE COMPOUNDS, PHARMACEUTICAL AGENTS CONTAINING THE SAME, AND THE USE THEREOF | MERCKLE GMBH (DE) | 2003-12-17 | — | — | EP | disclosed |
| EP-1246825-A1 | FUSED PYRROLE COMPOUNDS, PHARMACEUTICAL AGENTS CONTAINING THE SAME, AND THE USE THEREOF | MERCKLE GMBH (DE) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001051491-A1 | FUSED PYRROLE COMPOUNDS, PHARMACEUTICAL AGENTS CONTAINING THE SAME, AND THE USE THEREOF | MERCKLE GMBH (DE) | 2001-07-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040122002-A1 | Fused pyrrole compounds, pharmaceutical agents containing the same, and the use thereof | PTGS1, PTGS2, PTGER1 | PTGES 6/4885ALOX5 62/4885PTGS1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.