Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 16/20 | 0.62 |
| ▸ | SMO | Q99835 | 1/20 | 0.59 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.52 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.45 |
| ▸ | RAF1 | P04049 | 2/20 | 0.45 |
| ▸ | BRAF | P15056 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6476766 | 0.95 | OPRK1 (0.59) | MAPK14SMOOPRK1GPR119RAF1 | |
| SCHEMBL7809442 | 0.93 | MAPK14 (0.52) | MAPK14SMOOPRK1GPR119 | |
| SCHEMBL2972096 | 0.91 | OPRK1 (0.58) | MAPK14SMOOPRK1GPR119RAF1 | |
| SCHEMBL6533594 | 0.91 | OPRK1 (0.56) | MAPK14SMOOPRK1RAF1BRAF | |
| SCHEMBL6477326 | 0.90 | MAPK14 (0.54) | MAPK14SMOOPRK1 | |
| SCHEMBL7804552 | 0.89 | OPRK1 (0.54) | MAPK14SMOOPRK1GPR119 | |
| SCHEMBL6477083 | 0.88 | MAPK14 (0.54) | MAPK14SMOOPRK1BRAF | |
| SCHEMBL6477601 | 0.88 | OPRK1 (0.57) | MAPK14SMOOPRK1GPR119BRAF | |
| SCHEMBL6477163 | 0.87 | OPRK1 (0.58) | MAPK14SMOOPRK1GPR119BRAF | |
| SCHEMBL2979241 | 0.87 | OPRK1 (0.55) | MAPK14SMOOPRK1RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6956037-B2 | Benzamide derivatives for the treatment of diseases mediated by cytokines | ASTRAZENECA AB (SE) | 2005-10-18 | — | — | US | disclosed |
| US-6949814-B2 | Mounting material, semiconductor device and method of manufacturing semiconductor device | KABUSHIKI KAISHA TOSHIBA (JP) | 2005-09-27 | — | — | US | disclosed |
| EP-1077931-B1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | ASTRAZENECA AB (SE) | 2004-11-17 | — | — | EP | disclosed |
| US-20030212068-A1 | Benzamide derivatives for the treatment of diseases mediated by cytokines | ASTRAZENECA AB | 2003-11-13 | — | — | US | disclosed |
| US-6579872-B1 | Such as TNF, in particular of TNF alpha, and various interleukins, in particular IL-1; N-(5-(4-(3-hydroxypropoxy)benzamido)-2-methylphenyl)-3,4-dimethoxybenzamide | ASTRAZENECA AB (SE) | 2003-06-17 | — | — | US | disclosed |
| EP-1077931-A1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | AstraZeneca AB (SE) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999059959-A1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | ASTRAZENECA AB (SE) | 1999-11-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030212068-A1 | Benzamide derivatives for the treatment of diseases mediated by cytokines | IL2, IL6, IL6ST | MAPK14 2054/4885SMO 4147/4885OPRK1 924/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.