Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 3/20 | 0.39 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.37 |
| ▸ | CETP | P11597 | 11/20 | 0.35 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 2/20 | 0.34 |
| ▸ | ATP4A | P20648 | 1/20 | 0.34 |
| ▸ | ATP4B | P51164 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL648123 | 0.92 | C5AR1 (0.42) | CRHR1C5AR1CETPBCHEPPARG | |
| SCHEMBL652081 | 0.88 | BCHE (0.39) | CRHR1C5AR1ACKR3BCHEATP4A | |
| SCHEMBL650074 | 0.87 | C5AR1 (0.43) | CRHR1C5AR1CETP | |
| SCHEMBL5135861 | 0.84 | CRHR1 (0.44) | CRHR1C5AR1CETPBCHEATP4A | |
| SCHEMBL648926 | 0.84 | C5AR1 (0.41) | C5AR1CETP | |
| SCHEMBL651113 | 0.83 | CRHR1 (0.42) | CRHR1C5AR1CETP | |
| SCHEMBL651691 | 0.82 | C5AR1 (0.42) | CRHR1C5AR1BCHEATP4AATP4B | |
| SCHEMBL652216 | 0.82 | C5AR1 (0.42) | CRHR1C5AR1CETPPPARGPPARA | |
| SCHEMBL651407 | 0.82 | C5AR1 (0.42) | CRHR1C5AR1CETP | |
| SCHEMBL650496 | 0.80 | C5AR1 (0.40) | CRHR1C5AR1CETP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |