Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA3 | P07451 | 1/20 | 0.43 |
| ▸ | CA6 | P23280 | 1/20 | 0.43 |
| ▸ | CA5A | P35218 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.43 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | AHR | P35869 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.40 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26980813 | 0.84 | DYRK1A (0.49) | NR4A2DYRK1AHTR2ACA12CA1 | |
| SCHEMBL5730144 | 0.83 | NR4A2 (0.49) | NR4A2DYRK1AHTR2ACA12CA1 | |
| SCHEMBL6485937 | 0.79 | SLC6A4 (0.47) | NR4A2DYRK1AHTR2ACA12CA1 | |
| SCHEMBL23620164 | 0.76 | CSNK2A2 (0.50) | CA1CA2CA9 | |
| SCHEMBL30991305 | 0.76 | CSNK2A2 (0.50) | CA1CA2CA9 | |
| SCHEMBL28251367 | 0.73 | DYRK1A (0.60) | NR4A2DYRK1AHTR2ACA12CA1 | |
| SCHEMBL19836839 | 0.72 | DYRK1A (0.55) | NR4A2DYRK1AHTR2ADAOAHR | |
| SCHEMBL3057460 | 0.72 | TTR (0.60) | NR4A2TTR | |
| SCHEMBL2036977 | 0.71 | NR4A2 (0.69) | NR4A2DYRK1AHTR2APRKAB2PRKAG1 | |
| SCHEMBL31542356 | 0.71 | NR4A2 (0.69) | NR4A2DYRK1AHTR2APRKAB2PRKAG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6852726-B2 | Substituted indoles as alpha-1 agonists | SYNTEX LLC (US) | 2005-02-08 | — | — | US | disclosed |
| US-20030220319-A1 | Substituted indoles as alpha-1 agonists | SYNTEX (U.S.A.) LLC | 2003-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030220319-A1 | Substituted indoles as alpha-1 agonists | ADRA1A, ADRB1, ADRA1B | NR4A2 230/4885DYRK1A 1394/4885HTR2A 61/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.