Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 3/20 | 0.38 |
| ▸ | CES1 | P23141 | 2/20 | 0.38 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.38 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.37 |
| ▸ | XDH | P47989 | 2/20 | 0.37 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.37 |
| ▸ | TLR4 | O00206 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 5/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6463821 | 0.87 | DAGLA (0.40) | FAAHCES1DAGLAP2RY14XDH | |
| SCHEMBL7045310 | 0.79 | FAAH (0.38) | FAAHCES1DAGLAP2RY14XDH | |
| SCHEMBL6467434 | 0.78 | HDAC6 (0.40) | FAAHCES1DAGLAP2RY14XDH | |
| SCHEMBL7047033 | 0.75 | FAAH (0.41) | FAAHCES1DAGLAP2RY14XDH | |
| SCHEMBL6463510 | 0.75 | FAAH (0.41) | FAAHCES1DAGLAP2RY14XDH | |
| SCHEMBL7043208 | 0.72 | FAAH (0.41) | FAAHCES1DAGLAP2RY14XDH | |
| SCHEMBL6462832 | 0.72 | DAGLA (0.43) | FAAHCES1DAGLAP2RY14XDH | |
| SCHEMBL6478314 | 0.72 | CTSS (0.42) | CTSS | |
| SCHEMBL7188004 | 0.72 | FAAH (0.39) | FAAHCES1DAGLAXDHNLRP3 | |
| SCHEMBL7045307 | 0.72 | CTSS (0.42) | CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1516877-A1 | Amine derivatives as protease inhibitors | AXYS PHARMACEUTICALS, INC. (US) | 2005-03-23 | — | — | EP | disclosed |