SCHEMBL6478581

SCHEMBL6478581

C=CC(C)(C)Cc1ccc(C)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 1/20 0.39
THRA P10827 1/20 0.39
THRB P10828 1/20 0.39
CYP1A2 P05177 1/20 0.37
CYP2A6 P11509 1/20 0.37
TAAR1 Q96RJ0 1/20 0.37
TSHR P16473 1/20 0.36
ESR1 P03372 3/20 0.35
AGXT P21549 2/20 0.35
ATM Q13315 1/20 0.35
ACHE P22303 2/20 0.35
TDP1 Q9NUW8 1/20 0.35
HPGD P15428 1/20 0.34
SLC6A2 P23975 1/20 0.33
HTR2A P28223 1/20 0.33
SLC6A4 P31645 1/20 0.33
HRH1 P35367 1/20 0.33
HTR2B P41595 1/20 0.33
CHRNA4 P43681 1/20 0.33
SLC6A3 Q01959 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18230874 0.81 SLC6A4 (0.55) IDO1THRATHRBCYP1A2CYP2A6
SCHEMBL25393873 0.81 THRA (0.42) IDO1THRATHRBCYP1A2CYP2A6
SCHEMBL1072575 0.80 SLC6A2 (0.52) THRATHRBCYP1A2TAAR1ATM
SCHEMBL1216706 0.78 TSHR (0.47) IDO1THRATHRBCYP1A2CYP2A6
SCHEMBL10786742 0.78 ALDH1A1 (0.55) IDO1TAAR1TSHRAGXTTDP1
SCHEMBL24337015 0.77 IDO1 (0.38) IDO1THRATHRBCYP1A2CYP2A6
SCHEMBL25306760 0.77 THRA (0.34) THRATHRBTAAR1ESR1SLC6A2
SCHEMBL10921319 0.76 ESR1 (0.39) IDO1THRATHRBCYP1A2CYP2A6
SCHEMBL27884322 0.76 CYP1A2 (0.41) IDO1THRATHRBCYP1A2CYP2A6
SCHEMBL29281407 0.76 ESR1 (0.41) IDO1THRATHRBCYP1A2CYP2A6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005012209-A2 CATALYZED ENANTIOSELECTIVE TRANSFORMATION OF ALKENES UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2005-02-10 WO claimed
WO-2005012209-A2 CATALYZED ENANTIOSELECTIVE TRANSFORMATION OF ALKENES UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2005-02-10 WO disclosed