SCHEMBL6478650

SCHEMBL6478650

CC(C)(C)OC(=O)NC1[C@H]2CN(c3c(F)cc(N4C[C@H](CN)OC4=O)cc3F)C[C@@H]12

nearest known ligand 0.43

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
F10 P00742 3/20 0.43
MAOA P21397 6/20 0.42
MAOB P27338 6/20 0.39
CALML3 P27482 4/20 0.39
LMNA P02545 1/20 0.39
PTGS1 P23219 1/20 0.39
SDHA P31040 1/20 0.39
RORC P51449 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6478939 0.91 CALML3 (0.44) F10MAOAMAOBCALML3LMNA
SCHEMBL6339921 0.88 F10 (0.54) F10MAOAMAOBCALML3LMNA
SCHEMBL6478120 0.88 F10 (0.54) F10MAOAMAOBCALML3LMNA
SCHEMBL6477889 0.88 MAOA (0.54) F10MAOAMAOBCALML3LMNA
SCHEMBL6478555 0.87 MAOA (0.44) F10MAOAMAOBCALML3LMNA
SCHEMBL6484939 0.86 F10 (0.47) F10MAOAMAOBCALML3LMNA
SCHEMBL6487896 0.85 F10 (0.48) F10MAOAMAOBCALML3LMNA
SCHEMBL6210509 0.84 F10 (0.46) F10MAOAMAOBCALML3LMNA
SCHEMBL2480376 0.81 MAOA (0.48) F10MAOAMAOBCALML3LMNA
SCHEMBL18059593 0.81 MAOA (0.48) F10MAOAMAOBCALML3LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6875784-B2 Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives PHARMACIA & UPJOHN COMPANY (US) 2005-04-05 US disclosed
US-20040127530-A1 Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives PHARMACIA & UPJOHN COMPANY 2004-07-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040127530-A1 Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives OXA1L, CYP1B1, MT-CO1 F10 1247/4885MAOA 743/4885MAOB 739/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.