Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.55 |
| ▸ | CA12 | O43570 | 4/20 | 0.51 |
| ▸ | CA1 | P00915 | 4/20 | 0.51 |
| ▸ | CA2 | P00918 | 4/20 | 0.51 |
| ▸ | CA7 | P43166 | 4/20 | 0.51 |
| ▸ | CA9 | Q16790 | 4/20 | 0.51 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 3/20 | 0.42 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.42 |
| ▸ | HNF4A | P41235 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
| ▸ | PTPRC | P08575 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10424172 | 0.85 | PTPN11 (0.50) | PTPN11CA12CA1CA2CA7 | |
| SCHEMBL20772338 | 0.83 | PTPRC (0.40) | PTPN11CA12CA1CA2CA7 | |
| SCHEMBL8206002 | 0.80 | PTPN11 (0.66) | PTPN11CA12CA1CA2CA7 | |
| SCHEMBL22906952 | 0.80 | PTPN11 (0.40) | PTPN11CA12CA1CA2CA7 | |
| SCHEMBL7703308 | 0.79 | PTPN11 (0.68) | PTPN11CA12CA1CA2CA7 | |
| SCHEMBL6488780 | 0.78 | ALDH1A1 (0.42) | PTPN11LMNAEGFRGAAHPGD | |
| SCHEMBL3458276 | 0.77 | PTPN11 (0.51) | PTPN11CA12CA1CA2CA7 | |
| SCHEMBL7914505 | 0.77 | PTPN11 (0.65) | PTPN11CA12CA1CA2CA7 | |
| SCHEMBL8058019 | 0.77 | PTPN11 (0.58) | PTPN11CA12CA1CA2CA7 | |
| SCHEMBL22906997 | 0.76 | PTPN11 (0.44) | PTPN11CA12CA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6894059-B1 | Compounds and methods for treatment of asthma, allergy and inflammatory disorders | UCB S.A. (BE) | 2005-05-17 | — | — | US | disclosed |
| EP-1165533-B1 | COMPOUNDS AND METHODS FOR TREATMENT OF ASTHMA, ALLERGY AND INFLAMMATORY DISORDERS | UCB SA (BE) | 2004-10-13 | — | — | EP | disclosed |
| US-6797713-B2 | Compounds and methods for treatment of asthma, allergy and inflammatory disorders | UCB S.A. (BE) | 2004-09-28 | — | — | US | disclosed |
| EP-1418173-A1 | N-(3-butyn-1-yl) N-hydroxyurea | UCB, S.A. (BE) | 2004-05-12 | — | — | EP | disclosed |
| US-20040048875-A1 | Compounds and methods for treatment of asthma, allergy and inflammatory disorders | UCB S.A. | 2004-03-11 | — | — | US | disclosed |
| US-6686502-B1 | N-HYDROXYL-N-(3-BUTYNYL)-UREA CHEMICAL INTERMEDIATE FOR PIPERIDINE OR PIPERAZINE DERIVATIVES | UCB S.A. (BE) | 2004-02-03 | — | — | US | disclosed |
| US-20030220347-A1 | Compounds and methods for treatment of asthma, allergy and inflammatory disorders | UCB S.A. | 2003-11-27 | — | — | US | disclosed |
| US-6451801-B1 | 1,4-SUBSTITUTED PIPERIDINES AND PIPERAZINES | UCB, S.A. (BE) | 2002-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030220347-A1 | Compounds and methods for treatment of asthma, allergy and inflammatory disorders | HRH4, HRH2, HRH3 | PTPN11 1367/4885CA12 2430/4885CA1 1707/4885 |
| US-20040048875-A1 | Compounds and methods for treatment of asthma, allergy and inflammatory disorders | HRH4, HRH2, HRH3 | PTPN11 1367/4885CA12 2430/4885CA1 1707/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.