Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.30 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20768154 | 0.75 | KMT2A (0.38) | KMT2AKDM4EPOLBCYP11B1CYP11B2 | |
| SCHEMBL9238656 | 0.73 | KDM4E (0.44) | KMT2AKDM4ECYP11B1CYP11B2MEN1 | |
| SCHEMBL27476843 | 0.69 | CYP11B1 (0.40) | KMT2AKDM4EESR1CYP11B1CYP11B2 | |
| SCHEMBL871451 | 0.69 | ESR1 (0.57) | KMT2AKDM4EKIF11ESR1ESR2 | |
| Hydrochloric Acid SCHEMBL11846585 | 0.67 | ESR1 (0.55) | KMT2AKDM4EKIF11ESR1ESR2 | |
| SCHEMBL4543871 | 0.67 | CYP11B1 (0.43) | KMT2ACYP11B1CYP11B2LMNAADRA1D | |
| SCHEMBL1564248 | 0.67 | KCNN4 (0.40) | KMT2AKDM4EPOLBCYP11B1CYP11B2 | |
| SCHEMBL27469711 | 0.67 | KMT2A (0.38) | KMT2AKDM4EESR1CYP11B1CYP11B2 | |
| SCHEMBL6446028 | 0.66 | KMT2A (0.43) | KMT2AKDM4EESR1CYP11B1CYP11B2 | |
| SCHEMBL7246865 | 0.66 | KDM4E (0.39) | KDM4ECYP11B1CYP11B2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-8119687-B2 | Derivatives of dioxan-2-alkyl carbamates, preparation thereof and application thereof in therapeutics | SANOFI-AVENTIS (FR) | 2012-02-21 | — | — | US | disclosed |