Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20768154 | 0.83 | KMT2A (0.38) | KDM4EKMT2ACYP2D6MEN1CYP11B1 | |
| SCHEMBL5692289 | 0.83 | KDM4E (0.41) | KDM4EKMT2ACYP2D6MEN1 | |
| SCHEMBL8912082 | 0.79 | KDM4E (0.38) | KDM4EKMT2ACYP2D6MEN1 | |
| SCHEMBL6321358 | 0.78 | KDM4E (0.37) | KDM4EKMT2ACYP2D6MEN1 | |
| SCHEMBL392779 | 0.74 | CYP11B1 (0.43) | KMT2ACYP2D6MEN1CYP11B1CYP11B2 | |
| SCHEMBL6698149 | 0.74 | KMT2A (0.34) | KDM4EKMT2ACYP2D6MEN1CYP11B1 | |
| SCHEMBL7246865 | 0.73 | KDM4E (0.39) | KDM4ECYP2D6CYP11B1CYP11B2 | |
| SCHEMBL647941 | 0.73 | KMT2A (0.38) | KDM4EKMT2AMEN1CYP11B1CYP11B2 | |
| SCHEMBL7672726 | 0.71 | MAPT (0.67) | KDM4EKMT2ACYP2D6 | |
| SCHEMBL4543871 | 0.70 | CYP11B1 (0.43) | KMT2ACYP2D6MEN1CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675112-A1 | Imidazole-containing inhibitors of farnesyl protein transferase | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-10-04 | — | — | EP | disclosed |