SCHEMBL6479532

SCHEMBL6479532

[CH2]c1c(C)nc2ccccn12

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.54
ALDH1A1 P00352 6/20 0.52
KDM4E B2RXH2 5/20 0.52
HSD17B10 Q99714 5/20 0.52
GAA P10253 3/20 0.52
HPGD P15428 3/20 0.52
NPC1 O15118 1/20 0.52
GLA P06280 1/20 0.52
CASP1 P29466 1/20 0.52
CASP7 P55210 1/20 0.52
NPSR1 Q6W5P4 5/20 0.51
MAPK1 P28482 1/20 0.51
MEN1 O00255 1/20 0.47
CDK4 P11802 1/20 0.46
CDK2 P24941 1/20 0.46
LMNA P02545 1/20 0.45
CRHBP P24387 1/20 0.45
CRHR2 Q13324 1/20 0.45
POLB P06746 1/20 0.44
MAPT P10636 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL266148 0.79 KMT2A (0.58) KMT2AALDH1A1KDM4EHSD17B10GAA
SCHEMBL15004608 0.78 KMT2A (0.61) KMT2AALDH1A1KDM4EHSD17B10GAA
SCHEMBL18304943 0.76 KMT2A (0.54) KMT2AALDH1A1KDM4EHSD17B10GAA
SCHEMBL15004600 0.76 NPC1 (0.58) KMT2AALDH1A1KDM4EHSD17B10GAA
SCHEMBL16563652 0.76 KMT2A (0.54) KMT2AALDH1A1KDM4EHSD17B10GAA
SCHEMBL792006 0.76 KMT2A (0.59) KMT2AALDH1A1KDM4EHSD17B10GAA
SCHEMBL7965109 0.76 KMT2A (0.54) KMT2AALDH1A1KDM4EHSD17B10GAA
SCHEMBL18901345 0.76 KMT2A (0.54) KMT2AALDH1A1KDM4EHSD17B10GAA
SCHEMBL8829992 0.76 ALDH1A1 (0.52) KMT2AALDH1A1KDM4EHSD17B10GAA
SCHEMBL10424639 0.76 KMT2A (0.59) KMT2AALDH1A1KDM4EHSD17B10GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6962938-B2 Spiro-cyclic β-amino acid derivatives as inhibitors of matrix metalloproteases and TNF-α converting enzyme (TACE) BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) 2005-11-08 US disclosed
US-6720329-B2 ANTIINFLAMMATORY AGENTS BRISTOL-MYERS SQUIBB PHARMA 2004-04-13 US disclosed
EP-1373199-A4 SPIRO-CYCLIC BETA-AMINO ACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES AND TNF-ALPHA CONVERTING ENZYME (TAGE) BRISTOL MYERS SQUIBB PHARMA CO (US) 2004-04-07 EP disclosed
EP-1373199-A2 SPIRO-CYCLIC BETA-AMINO ACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES AND TNF-ALPHA CONVERTING ENZYME (TAGE) Bristol-Myers Squibb Pharma Company (US) 2004-01-02 EP disclosed
WO-2002074738-A2 SPIRO-CYCLIC BETA-AMINO ACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES AND TNF-ALPHA CONVERTING ENZYME (TAGE) BRISTOL-MYERS SQUIBB COMPANY (US) 2002-09-26 WO disclosed