Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.38 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.37 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6494742 | 0.91 | AKR1C3 (0.40) | AKR1C3AKR1C2GAAL3MBTL1 | |
| SCHEMBL6490426 | 0.89 | RORC (0.38) | AKR1C3AKR1C2TUBB1 | |
| SCHEMBL6479624 | 0.86 | BRPF1 (0.43) | AKR1C3AKR1C2BRPF1TUBB1LMNA | |
| SCHEMBL6480163 | 0.84 | AKR1C3 (0.44) | AKR1C3AKR1C2BRPF1TUBB1LMNA | |
| SCHEMBL6490788 | 0.82 | TUBB1 (0.50) | AKR1C3AKR1C2BRPF1TUBB1LMNA | |
| SCHEMBL6480444 | 0.80 | MAPT (0.42) | LMNASMN1; SMN2HTTALDH1A1HPGD | |
| SCHEMBL6253573 | 0.78 | BRPF1 (0.41) | AKR1C3AKR1C2BRPF1TUBB1SMN1; SMN2 | |
| SCHEMBL6749324 | 0.76 | BRPF1 (0.46) | AKR1C3AKR1C2BRPF1TUBB1GAA | |
| SCHEMBL6489116 | 0.75 | HSD17B10 (0.44) | LMNASMN1; SMN2GAAHTTJAK1 | |
| SCHEMBL6480722 | 0.74 | NPSR1 (0.49) | LMNASMN1; SMN2KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050215614-A1 | Substituted indoles and their use as hcv inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2005-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050215614-A1 | Substituted indoles and their use as hcv inhibitors | IDO1, IDO2, HAVCR2 | AKR1C3 1399/4885AKR1C2 1501/4885BRPF1 3594/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.