Sugi Predict

Sugi Predict / Compounds / SCHEMBL6480175

SCHEMBL6480175

SCHEMBL6480175

CON(C)C(=O)C(Cl)(c1ccc(Cl)cc1)c1ccc(-n2ncc(=O)[nH]c2=O)cc1

nearest known ligand 0.40

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 4/20 0.40
▸ KMT2A Q03164 4/20 0.40
▸ NR1I2 O75469 1/20 0.40
▸ P2RX7 Q99572 10/20 0.39
▸ ABCB11 O95342 1/20 0.36
▸ NPBWR1 P48145 1/20 0.35
▸ ALDH1A1 P00352 2/20 0.35
▸ LMNA P02545 2/20 0.35
▸ TSHR P16473 2/20 0.35
▸ NPSR1 Q6W5P4 1/20 0.35
▸ MAPT P10636 1/20 0.34
▸ THRB P10828 2/20 0.34
▸ HPGD P15428 1/20 0.34
▸ HTT P42858 1/20 0.34
▸ SMN1; SMN2 Q16637 1/20 0.34
▸ THRA P10827 1/20 0.34
▸ NPC1 O15118 1/20 0.33
▸ RAB9A P51151 1/20 0.33
▸ L3MBTL1 Q9Y468 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10395311 0.85 P2RX7 (0.43) MEN1KMT2ANR1I2P2RX7ABCB11
SCHEMBL10395695 0.82 KMT2A (0.46) MEN1KMT2ANR1I2P2RX7ABCB11
SCHEMBL5567164 0.82 KMT2A (0.46) MEN1KMT2ANR1I2P2RX7ABCB11
SCHEMBL6490494 0.82 KMT2A (0.46) MEN1KMT2ANR1I2P2RX7ABCB11
SCHEMBL5561470 0.78 KMT2A (0.47) MEN1KMT2ANR1I2P2RX7ABCB11
SCHEMBL7909905 0.76 KMT2A (0.58) MEN1KMT2ANR1I2P2RX7ABCB11
SCHEMBL6479192 0.73 KMT2A (0.50) MEN1KMT2ANR1I2P2RX7ABCB11
SCHEMBL8603426 0.73 KMT2A (0.54) MEN1KMT2ANR1I2P2RX7ABCB11
SCHEMBL27571832 0.73 KMT2A (0.46) MEN1KMT2ANR1I2P2RX7ABCB11
SCHEMBL6480171 0.73 MEN1 (0.49) MEN1KMT2ANR1I2P2RX7ABCB11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6951857-B2 Interleukins; cytokines; for treating eosinophil-dependent inflammatory disease/bronchial asthma FREYNE EDDY JEAN EDGARD 2005-10-04 — — US disclosed
US-6743792-B2 ANTIINFLAMMATORY AGENTS JANSSEN PHARMACEUTICA N.V. (BE) 2004-06-01 — — US disclosed
US-20030220331-A1 Interleukins; cytokines; for treating eosinophil-dependent inflammatory disease/bronchial asthma FREYNE EDDY JEAN EDGARD (BE) 2003-11-27 — — US disclosed
US-20020042416-A1 Antiinflammatory agents FREYNE EDDY JEAN EDGARD (BE) 2002-04-11 — — US disclosed
EP-1003729-A1 6-AZAURACIL DERIVATIVES AS IL-5 INHIBITORS JANSSEN PHARMACEUTICA N.V. (BE) 2000-05-31 — — EP disclosed
WO-1999002504-A1 6-AZAURACIL DERIVATIVES AS IL-5 INHIBITORS JANSSEN PHARMACEUTICA N.V. (BE) 1999-01-21 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020042416-A1 Antiinflammatory agents CCR1, CCR6, FPR1 MEN1 4743/4885KMT2A 4147/4885NR1I2 384/4885
US-20030220331-A1 Interleukins; cytokines; for treating eosinophil-dependent inflammatory disease/bronchial asthma IL6, CCR1, CCR6 MEN1 4804/4885KMT2A 3682/4885NR1I2 624/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.