Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.53 |
| ▸ | RORB | Q92753 | 1/20 | 0.49 |
| ▸ | CDK4 | P11802 | 1/20 | 0.46 |
| ▸ | CCND1 | P24385 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3128352 | 0.86 | LTB4R2 (0.50) | RORBCDK4CCND1NR1H4MEN1 | |
| SCHEMBL27799155 | 0.84 | RORB (0.51) | TRPV1RORBCDK4CCND1MAPT | |
| SCHEMBL14102268 | 0.84 | BCAT2 (0.65) | TRPV1RORBCDK4CCND1CHEK1 | |
| SCHEMBL171542 | 0.84 | TRPV1 (0.54) | TRPV1SMN1; SMN2SLC6A3SLC6A4 | |
| SCHEMBL19582847 | 0.84 | RORB (0.48) | TRPV1RORBCDK4CCND1MAPT | |
| SCHEMBL30892680 | 0.84 | BCAT2 (0.65) | TRPV1RORBCDK4CCND1CHEK1 | |
| SCHEMBL23354290 | 0.81 | SLC6A3 (0.67) | RORBCDK4CCND1MAPTNPSR1 | |
| SCHEMBL14102364 | 0.81 | CDK4 (0.52) | TRPV1RORBCDK4CCND1NR1H4 | |
| SCHEMBL29979412 | 0.81 | SLC6A3 (0.67) | RORBCDK4CCND1MAPTNPSR1 | |
| SCHEMBL29971478 | 0.81 | CDK4 (0.52) | TRPV1RORBCDK4CCND1NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542692-A1 | AMINO-PYRIDINE, -PYRIDINE AND PYRIDAZINE DERIVATIVES FOR USE AS VANILLOID RECEPTOR LIGANDS FOR THE TREATMENT OF PAIN | Amgen Inc. (US) | 2005-06-22 | — | — | EP | disclosed |
| WO-2003099284-A1 | AMINO-PYRIDINE, -PYRIDINE AND PYRIDAZINE DERIVATIVES FOR USE AS VANILLOID RECEPTOR LIGANDS FOR THE TREATMENT OF PAIN | AMGEN INC. (US) | 2003-12-04 | — | — | WO | disclosed |