Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.74 |
| ▸ | LMNA | P02545 | 2/20 | 0.74 |
| ▸ | MAPT | P10636 | 2/20 | 0.74 |
| ▸ | NPC1 | O15118 | 1/20 | 0.74 |
| ▸ | TP53 | P04637 | 1/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.74 |
| ▸ | MAOA | P21397 | 1/20 | 0.74 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.74 |
| ▸ | RAB9A | P51151 | 1/20 | 0.74 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.74 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.59 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.59 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.59 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.56 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.54 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.50 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.49 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nabumetone SCHEMBL29570823 | 0.85 | CYP1A2 (1.00) | CYP1A2KDM4ELMNAMAPTNPC1 | |
| Nabumetone SCHEMBL3853067 | 0.85 | CYP1A2 (1.00) | CYP1A2KDM4ELMNAMAPTNPC1 | |
| Nabumetone SCHEMBL2256 | 0.85 | CYP1A2 (1.00) | CYP1A2KDM4ELMNAMAPTNPC1 | |
| SCHEMBL1403565 | 0.85 | CYP1A2 (0.77) | CYP1A2KDM4ELMNAMAPTNPC1 | |
| Nabumetone SCHEMBL29373228 | 0.85 | CYP1A2 (1.00) | CYP1A2KDM4ELMNAMAPTNPC1 | |
| SCHEMBL27706724 | 0.85 | CYP1A2 (0.77) | CYP1A2KDM4ELMNAMAPTNPC1 | |
| SCHEMBL925662 | 0.84 | F2RL1 (0.68) | NPC1RAB9ASMN1; SMN2F2RL1ALDH1A1 | |
| SCHEMBL18096515 | 0.84 | CYP1A2 (0.74) | CYP1A2KDM4ELMNAMAPTNPC1 | |
| Nabumetone SCHEMBL104942 | 0.84 | CYP1A2 (0.97) | CYP1A2KDM4ELMNAMAPTNPC1 | |
| SCHEMBL4712374 | 0.84 | CYP1A2 (0.74) | CYP1A2KDM4ELMNAMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532098-A1 | PROCESS FOR PREPARING NITROOXYDERIVATIVES OF NAPROXEN | Nicox S.A. (FR) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004020384-A1 | PROCESS FOR PREPARING NITROOXYDERIVATIVES OF NAPROXEN | NICOX S.A. (FR) | 2004-03-11 | — | — | WO | disclosed |
| US-5290478-A | Nitrile containing naphthylene compound | SANYO CHEMICAL INDUSTRIES, LTD. (JP) | 1994-03-01 | — | — | US | disclosed |
| US-5160662-A | Improved response times | SANYO CHEMICAL INDUSTRIES, LTD. (JP) | 1992-11-03 | — | — | US | disclosed |
| EP-0385692-A2 | Optcally active compounds | SANYO CHEMICAL INDUSTRIES LTD. (JP) | 1990-09-05 | — | — | EP | disclosed |
| US-4704392-A | VIRICIDES | SYNTEX (U.S.A.) INC. (US) | 1987-11-03 | — | — | US | disclosed |
| US-4605659-A | HERPES; HEPATITUS | SYNTEX (U.S.A.) INC. (US) | 1986-08-12 | — | — | US | disclosed |