Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 1/20 | 0.40 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 7/20 | 0.40 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.40 |
| ▸ | MME | P08473 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL649425 | 0.91 | KMT2A (0.37) | LPAR1LPAR5AGTR1MMEKMT2A | |
| SCHEMBL648513 | 0.90 | HDAC1 (0.40) | LPAR1LPAR5AGTR1AGTR2KMT2A | |
| SCHEMBL650060 | 0.88 | LTB4R2 (0.38) | LPAR1LPAR5AGTR1AGTR2KMT2A | |
| SCHEMBL648120 | 0.86 | SMPD1 (0.38) | KMT2A | |
| SCHEMBL648465 | 0.86 | RORC (0.36) | KMT2A | |
| SCHEMBL650477 | 0.85 | KMT2A (0.34) | KMT2A | |
| SCHEMBL652317 | 0.85 | AGTR1 (0.43) | AGTR1AGTR2 | |
| SCHEMBL1913100 | 0.83 | C5AR1 (0.42) | AGTR1AGTR2KMT2ALTA4H | |
| SCHEMBL648906 | 0.82 | HDAC1 (0.39) | LPAR1LPAR5AGTR1KMT2A | |
| SCHEMBL648502 | 0.82 | LTA4H (0.42) | AGTR1AGTR2LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |