Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 5/20 | 0.47 |
| ▸ | P2RY12 | Q9H244 | 4/20 | 0.47 |
| ▸ | PDE2A | O00408 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6482033 | 0.92 | ALDH1A1 (0.54) | ALDH1A1KDM4EHPGDMAPTNPSR1 | |
| SCHEMBL6484336 | 0.85 | PDE3B (0.50) | ALDH1A1KDM4EHPGDPDE3APDE3B | |
| SCHEMBL6475029 | 0.84 | PDE3B (0.47) | PDE3APDE3BP2RY12PDE2ADYRK1A | |
| SCHEMBL6484254 | 0.84 | PDE3B (0.50) | ALDH1A1KDM4EHPGDMAPTNPSR1 | |
| SCHEMBL6485249 | 0.84 | PDE3B (0.50) | ALDH1A1KDM4EPDE3APDE3BP2RY12 | |
| SCHEMBL6484943 | 0.83 | PDE3B (0.48) | ALDH1A1KDM4EHPGDMAPTNPSR1 | |
| SCHEMBL6484869 | 0.83 | PDE3B (0.49) | ALDH1A1KDM4EPDE3APDE3BP2RY12 | |
| SCHEMBL6481683 | 0.83 | PDE3B (0.49) | ALDH1A1KDM4EPDE3APDE3BP2RY12 | |
| SCHEMBL2326950 | 0.82 | PDE3B (0.45) | ALDH1A1KDM4EHPGDMAPTNPSR1 | |
| SCHEMBL6476172 | 0.82 | PDE3B (0.48) | ALDH1A1KDM4EHPGDPDE3APDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1404321-A1 | 1-ALKYL-2-ARYL-BENZIMIDAZOLE DERIVATIVES, THEIR USE FOR PRODUCING MEDICAMENTS AND PHARMACEUTICAL PREPARATIONS CONTAINING SAID DERIVATIVES | Schering Aktiengesellschaft (DE) | 2004-04-07 | — | — | EP | claimed |
| US-20030055057-A1 | 1-alkyl-2-aryl-benzimidazole derivatives, their use for the production of pharmaceutial agents as well as pharmaceutical preparations that contain these derivatives | SCHERING AG (DE) | 2003-03-20 | — | — | US | claimed |
| WO-2003004023-A1 | 1-ALKYL-2-ARYL-BENZIMIDAZOLE DERIVATIVES, THEIR USE FOR PRODUCING MEDICAMENTS AND PHARMACEUTICAL PREPARATIONS CONTAINING SAID DERIVATIVES | SCHERING AKTIENGESELLSCHAFT (DE) | 2003-01-16 | — | — | WO | claimed |
| US-6855714-B2 | 1-alkyl-2-aryl-benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 2005-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030055057-A1 | 1-alkyl-2-aryl-benzimidazole derivatives, their use for the production of pharmaceutial agents as well as pharmaceutical preparations that contain these derivatives | ARG2, MSR1, ARG1 | ALDH1A1 182/4885KDM4E 1512/4885HPGD 800/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.