Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 3/20 | 0.47 |
| ▸ | FNTB | P49356 | 3/20 | 0.47 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.46 |
| ▸ | DRD3 | P35462 | 3/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | PTAFR | P25105 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3077208 | 0.99 | FNTA (0.47) | FNTAFNTBOPRL1DRD3DRD2 | |
| SCHEMBL6163043 | 0.89 | ALDH1A1 (0.43) | FNTAFNTBOPRL1DRD3DRD2 | |
| SCHEMBL6271049 | 0.86 | OPRL1 (0.46) | OPRL1DRD3DRD2PTAFRHTR1A | |
| SCHEMBL3074401 | 0.80 | DRD3 (0.57) | OPRL1DRD3DRD2CYP3A4CYP2C9 | |
| SCHEMBL3074404 | 0.80 | DRD3 (0.57) | OPRL1DRD3DRD2CYP3A4CYP2C9 | |
| SCHEMBL3073089 | 0.80 | DRD3 (0.57) | OPRL1DRD3DRD2CYP3A4CYP2C9 | |
| SCHEMBL3073087 | 0.80 | DRD3 (0.57) | OPRL1DRD3DRD2CYP3A4CYP2C9 | |
| SCHEMBL7672874 | 0.80 | CHRNA7 (0.57) | DRD3DRD2PTAFRHTR1AALDH1A1 | |
| SCHEMBL21245369 | 0.80 | HDAC8 (0.52) | PTAFRALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL3081179 | 0.79 | DRD2 (0.58) | FNTAFNTBOPRL1DRD3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6903118-B1 | Piperazinyl-substituted pyridylalkane, alkene and alkine carboxamides | KLINGE PHARMA GMBH (DE) | 2005-06-07 | — | — | US | claimed |