Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | IDO1 | P14902 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4965696 | 0.82 | MAPT (0.50) | ALDH1A1IDO1SMN1; SMN2HTTNPC1 | |
| SCHEMBL28102421 | 0.79 | PLAU (0.45) | ALDH1A1SMN1; SMN2HTTNPC1RAB9A | |
| SCHEMBL1446254 | 0.78 | HPGD (0.46) | SMN1; SMN2NPC1RAB9AMAPTTP53 | |
| SCHEMBL28102437 | 0.75 | CCR5 (0.42) | IDO1SMN1; SMN2HTTNPC1RAB9A | |
| SCHEMBL18171756 | 0.74 | ALDH1A1 (0.66) | ALDH1A1IDO1SMN1; SMN2HTTNPC1 | |
| SCHEMBL8807329 | 0.73 | IDO1 (0.46) | ALDH1A1IDO1SMN1; SMN2HTTNPC1 | |
| SCHEMBL693871 | 0.73 | SYK (0.54) | ALDH1A1SMN1; SMN2MAPTHPGDFFAR1 | |
| SCHEMBL30342568 | 0.70 | ALDH1A1 (0.57) | ALDH1A1IDO1SMN1; SMN2HTTNPC1 | |
| SCHEMBL2292785 | 0.70 | ALDH1A1 (0.57) | ALDH1A1IDO1SMN1; SMN2HTTNPC1 | |
| SCHEMBL693190 | 0.70 | MRGPRX4 (0.51) | IDO1FFAR4MRGPRX4FFAR1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6881737-B2 | Substituted triazinyl acrylamide derivatives and methods of use | AMGEN INC. (US) | 2005-04-19 | — | — | US | disclosed |
| EP-1390354-A1 | TRIAZINYL ACRYLAMIDE DERIVATIVES AS KINASE INHIBITORS | Amgen Inc. (US) | 2004-02-25 | — | — | EP | disclosed |
| WO-2002083653-A1 | TRIAZINYL ACRYLAMIDE DERIVATIVES AS KINASE INHIBITORS | AMGEN INC. (US) | 2002-10-24 | — | — | WO | disclosed |