Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 4/20 | 0.54 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.54 |
| ▸ | PPARG | P37231 | 6/20 | 0.49 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.47 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.46 |
| ▸ | PDE2A | O00408 | 1/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6474853 | 0.83 | ALDH1A1 (0.51) | PLA2G2APDE2APDE3BPDE3AP2RY12 | |
| SCHEMBL6474737 | 0.78 | PDE3B (0.51) | PDE2APDE3BPDE3AP2RY12 | |
| SCHEMBL7359072 | 0.75 | KDM4E (0.52) | AGTR1AGTR2PPARG | |
| SCHEMBL6483459 | 0.75 | GAA (0.51) | PLA2G2APDE2APDE3BPDE3AP2RY12 | |
| SCHEMBL5407925 | 0.74 | PDE3B (0.51) | PPARGPDE2APDE3BPDE3AP2RY12 | |
| SCHEMBL5412749 | 0.74 | PDE3B (0.53) | PPARGPDE2APDE3BPDE3AP2RY12 | |
| SCHEMBL5424244 | 0.74 | PDE3B (0.45) | PPARGPDE2APDE3BPDE3AP2RY12 | |
| SCHEMBL6476128 | 0.74 | HPGD (0.55) | PDE2APDE3BPDE3AP2RY12 | |
| SCHEMBL6474225 | 0.74 | PDE6D (0.49) | PLA2G2APDE3BPDE3AP2RY12 | |
| SCHEMBL5481606 | 0.74 | PDE3B (0.46) | PPARGPDE2APDE3BPDE3AP2RY12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6855714-B2 | 1-alkyl-2-aryl-benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 2005-02-15 | — | — | US | disclosed |