Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 7/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 7/20 | 0.51 |
| ▸ | P2RY12 | Q9H244 | 6/20 | 0.51 |
| ▸ | PDE2A | O00408 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.48 |
| ▸ | ACSS2 | Q9NR19 | 2/20 | 0.46 |
| ▸ | PIN1 | Q13526 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | TOP1 | P11387 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6476128 | 0.92 | HPGD (0.55) | PDE3BPDE3AP2RY12PDE2AKDM4E | |
| SCHEMBL6482127 | 0.92 | PTGER4 (0.49) | PDE3BPDE3AP2RY12PDE2AGAA | |
| SCHEMBL6484336 | 0.91 | PDE3B (0.50) | PDE3BPDE3AP2RY12PDE2AKDM4E | |
| SCHEMBL6483459 | 0.89 | GAA (0.51) | PDE3BPDE3AP2RY12PDE2AGAA | |
| SCHEMBL6474853 | 0.89 | ALDH1A1 (0.51) | PDE3BPDE3AP2RY12PDE2AKDM4E | |
| SCHEMBL6475372 | 0.88 | PDE3B (0.57) | PDE3BPDE3AP2RY12PDE2ALTB4R | |
| SCHEMBL7112442 | 0.88 | MAPT (0.53) | GAAKDM4EALDH1A1LMNATSHR | |
| SCHEMBL6484039 | 0.87 | KDM4E (0.51) | PDE3BPDE3AP2RY12PDE2AKDM4E | |
| SCHEMBL6484042 | 0.86 | TSPO (0.47) | PDE3BPDE3AP2RY12PDE2AGAA | |
| SCHEMBL6475559 | 0.86 | PDE3B (0.47) | PDE3BPDE3AP2RY12PDE2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6855714-B2 | 1-alkyl-2-aryl-benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 2005-02-15 | — | — | US | claimed |
| US-20030055057-A1 | 1-alkyl-2-aryl-benzimidazole derivatives, their use for the production of pharmaceutial agents as well as pharmaceutical preparations that contain these derivatives | SCHERING AG (DE) | 2003-03-20 | — | — | US | claimed |
| US-6855714-B2 | 1-alkyl-2-aryl-benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 2005-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030055057-A1 | 1-alkyl-2-aryl-benzimidazole derivatives, their use for the production of pharmaceutial agents as well as pharmaceutical preparations that contain these derivatives | ARG2, MSR1, ARG1 | PDE3B 210/4885PDE3A 226/4885P2RY12 562/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.