Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 11/20 | 0.60 |
| ▸ | CASP8 | Q14790 | 5/20 | 0.60 |
| ▸ | CASP3 | P42574 | 3/20 | 0.60 |
| ▸ | IL1B | P01584 | 2/20 | 0.46 |
| ▸ | LCK | P06239 | 8/20 | 0.45 |
| ▸ | MME | P08473 | 1/20 | 0.44 |
| ▸ | ACE | P12821 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2218068 | 1.00 | CASP1 (0.60) | CASP1CASP8CASP3IL1BLCK | |
| SCHEMBL645072 | 0.95 | CASP1 (0.64) | CASP1CASP8CASP3IL1BLCK | |
| SCHEMBL646077 | 0.95 | CASP1 (0.64) | CASP1CASP8CASP3IL1BLCK | |
| SCHEMBL647045 | 0.95 | CASP1 (0.64) | CASP1CASP8CASP3IL1BLCK | |
| SCHEMBL10200180 | 0.95 | CASP1 (0.64) | CASP1CASP8CASP3IL1BLCK | |
| SCHEMBL1409818 | 0.95 | CASP1 (0.64) | CASP1CASP8CASP3IL1BLCK | |
| SCHEMBL10200229 | 0.93 | CASP1 (0.62) | CASP1CASP8CASP3IL1BLCK | |
| SCHEMBL1410320 | 0.92 | CASP1 (0.60) | CASP1CASP8CASP3IL1BLCK | |
| SCHEMBL10200136 | 0.91 | CASP1 (0.60) | CASP1CASP8CASP3IL1BLCK | |
| SCHEMBL644708 | 0.91 | CASP1 (0.62) | CASP1CASP8CASP3IL1BLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165319-A1 | INHIBITORS OF INTERLEUKIN-1 BETA CONVERTING ENZYME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-06-28 | — | — | US | disclosed |
| US-8119631-B2 | Inhibitors of interleukin-1β converting enzyme | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-02-21 | — | — | US | disclosed |
| US-7790713-B2 | Inhibitors of interleukin-1β converting enzyme | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-09-07 | — | — | US | disclosed |
| US-20080039449-A1 | Inhibitors of interleukin-1beta converting enzyme | BATCHELOR MARK J | 2008-02-14 | — | — | US | disclosed |
| US-20050143436-A1 | Inhibitors of interleukin-1beta converting enzyme | VERTEX PHARMACEUTICALS INCORPORATED | 2005-06-30 | — | — | US | disclosed |
| US-6258948-B1 | AN N-ACYLAMINO COMPOUND; ANTIINFLAMMATORY AGENTS, AUTOIMMUNE DISEASES | VERTEX PHARMACEUTICALS, INCORPORATED | 2001-07-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165319-A1 | INHIBITORS OF INTERLEUKIN-1 BETA CONVERTING ENZYME | IL1A, IFNAR1, IL1B | CASP1 6/4885CASP8 131/4885CASP3 85/4885 |
| US-20080039449-A1 | Inhibitors of interleukin-1beta converting enzyme | IL1A, IL1B, IFNAR1 | CASP1 5/4885CASP8 115/4885CASP3 67/4885 |
| US-20050143436-A1 | Inhibitors of interleukin-1beta converting enzyme | IL1A, IL1B, IFNAR1 | CASP1 5/4885CASP8 123/4885CASP3 73/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.