Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 7/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 7/20 | 0.32 |
| ▸ | HTR2A | P28223 | 4/20 | 0.32 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7159370 | 0.78 | PTPRF (0.36) | HTR2BMAPTLMNATP53CYP1A2 | |
| SCHEMBL6488239 | 0.77 | CNR2 (0.35) | HTR2BMAPTLMNATP53CYP1A2 | |
| SCHEMBL2644762 | 0.73 | MAPT (0.42) | HTR2BMAPTLMNATP53CYP1A2 | |
| SCHEMBL16046136 | 0.72 | MAPT (0.41) | HTR2BMAPTLMNATP53CYP1A2 | |
| SCHEMBL6672104 | 0.69 | CUL4A (0.40) | HTR2BMAPTLMNATP53CYP1A2 | |
| SCHEMBL10533506 | 0.69 | MAPT (0.39) | HTR2BMAPTLMNATP53CYP1A2 | |
| SCHEMBL3865099 | 0.68 | MAPT (0.37) | HTR2BMAPTLMNATP53CYP1A2 | |
| SCHEMBL10707636 | 0.66 | MAPT (0.52) | HTR2BMAPTLMNATP53CYP1A2 | |
| SCHEMBL27932143 | 0.62 | MAPT (0.65) | HTR2BMAPTLMNATP53CYP1A2 | |
| SCHEMBL16174791 | 0.59 | KDM1A (0.44) | HTR2BMAPTLMNATP53CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6964981-B2 | Tetrahydrofuran derivatives and their use as NK-1 antagonists | MERCK SHARP & DOHME LTD. (GB) | 2005-11-15 | — | — | US | disclosed |
| US-20030199500-A1 | Tetrahydrofuran derivatives and their use as nk-1 antagonists | MERCK SHARP & DOHME LTD. (GB) | 2003-10-23 | — | — | US | disclosed |
| EP-1322629-A1 | TETRAHYDROFURAN DERIVATIVES AND THEIR USE AS NK-1 ANTAGONISTS | Merck Sharp & Dohme Limited (GB) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002024673-A1 | TETRAHYDROFURAN DERIVATIVES AND THEIR USE AS NK-1 ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 2002-03-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030199500-A1 | Tetrahydrofuran derivatives and their use as nk-1 antagonists | GRIK1, OPRK1, GRIK5 | HTR2B 230/4885MAPT 4057/4885LMNA 3985/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.