SCHEMBL16046136

SCHEMBL16046136

O=C1OC=C(c2ccccc2)C1c1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.41
LMNA P02545 3/20 0.41
CYP3A4 P08684 2/20 0.41
TP53 P04637 1/20 0.41
CYP1A2 P05177 1/20 0.41
MAPK1 P28482 1/20 0.41
HTR2B P41595 1/20 0.41
CFTR P13569 1/20 0.41
GOPC Q9HD26 1/20 0.41
KMT2A Q03164 3/20 0.36
MEN1 O00255 2/20 0.36
POLB P06746 2/20 0.36
GAA P10253 2/20 0.36
SMN1; SMN2 Q16637 1/20 0.34
RAB9A P51151 1/20 0.33
SLC6A3 Q01959 1/20 0.33
PTPN1 P18031 1/20 0.33
ABL1 P00519 1/20 0.33
RIN1 Q13671 1/20 0.33
KDM4E B2RXH2 3/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6376816 0.83 PTGS2 (0.45) ALDH1A1
SCHEMBL14163960 0.83 PTGS2 (0.45) ALDH1A1
SCHEMBL5327141 0.82 GAA (0.31) MAPTLMNACYP3A4TP53CYP1A2
SCHEMBL14168700 0.80 MMP2 (0.34) MAPTALDH1A1CA2CA1
SCHEMBL2644762 0.74 MAPT (0.42) MAPTLMNACYP3A4TP53CYP1A2
SCHEMBL7546321 0.74 CYP2C9 (0.34) MAPTLMNACYP3A4TP53CYP1A2
SCHEMBL6486287 0.72 HTR2B (0.39) MAPTLMNACYP3A4TP53CYP1A2
SCHEMBL10533506 0.70 MAPT (0.39) MAPTLMNACYP3A4TP53CYP1A2
SCHEMBL6672104 0.70 CUL4A (0.40) MAPTLMNACYP3A4TP53CYP1A2
SCHEMBL9510311 0.70 PIM1 (0.41) MAPTLMNACFTRGOPCKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160029644-A1 Methods and Compositions for Weed Control MONSATO TECHNOLOGY LLC (US) 2016-02-04 US claimed
US-20160015035-A1 Methods and Compositions for Weed Control MONSANTO TECHNOLOGY LLC (US) 2016-01-21 US claimed
EP-2971185-A1 METHODS AND COMPOSITIONS FOR WEED CONTROL Monsanto Technology LLC (US) 2016-01-20 EP claimed
EP-2970973-A1 METHODS AND COMPOSITIONS FOR WEED CONTROL Monsanto Technology LLC (US) 2016-01-20 EP claimed
EP-2967082-A2 METHODS AND COMPOSITIONS FOR WEED CONTROL Monsanto Technology LLC (US) 2016-01-20 EP claimed
WO-2014164797-A2 METHODS AND COMPOSITIONS FOR WEED CONTROL MONSANTO TECHNOLOGY LLC (US) 2014-10-09 WO claimed
WO-2014164761-A1 METHODS AND COMPOSITIONS FOR WEED CONTROL MONSANTO TECHNOLOGY LLC (US) 2014-10-09 WO claimed
WO-2014151255-A1 METHODS AND COMPOSITIONS FOR WEED CONTROL MONSANTO TECHNOLOGY LLC (US) 2014-09-25 WO claimed
US-20140274712-A1 METHODS AND COMPOSITIONS FOR WEED CONTROL MONSANTO TECHNOLOGY LLC (US) 2014-09-18 US claimed
EP-2970973-B1 METHODS AND COMPOSITIONS FOR WEED CONTROL MONSANTO TECHNOLOGY LLC (US) 2020-10-14 EP disclosed
US-10568328-B2 Methods and compositions for weed control MONSANTO TECHNOLOGY LLC (US) 2020-02-25 US disclosed
EP-3604535-A2 METHODS AND COMPOSITIONS FOR WEED CONTROL Monsanto Technology LLC (US) 2020-02-05 EP disclosed
EP-2970973-A1 METHODS AND COMPOSITIONS FOR WEED CONTROL Monsanto Technology LLC (US) 2016-01-20 EP disclosed
WO-2014151255-A1 METHODS AND COMPOSITIONS FOR WEED CONTROL MONSANTO TECHNOLOGY LLC (US) 2014-09-25 WO disclosed
US-20140274712-A1 METHODS AND COMPOSITIONS FOR WEED CONTROL MONSANTO TECHNOLOGY LLC (US) 2014-09-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160015035-A1 Methods and Compositions for Weed Control NOTUM, LOXL3, CXXC5 MAPT 4321/4885LMNA 2042/4885CYP3A4 4383/4885
US-20140274712-A1 METHODS AND COMPOSITIONS FOR WEED CONTROL CYC1, PRDX5, CYCS MAPT 3158/4885LMNA 3565/4885CYP3A4 2388/4885
US-20160029644-A1 Methods and Compositions for Weed Control AS3MT, NOTUM, POLR1C MAPT 4858/4885LMNA 3185/4885CYP3A4 2382/4885
US-10568328-B2 Methods and compositions for weed control CYC1, PRDX5, CYCS MAPT 3158/4885LMNA 3565/4885CYP3A4 2388/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.