SCHEMBL6486764

SCHEMBL6486764

Cc1cc(C(=O)O)cc2c1nc(C)n2Cc1ccc(-c2ccccc2)cc1Cl

nearest known ligand 0.44

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
DCTPP1 Q9H773 3/20 0.44
ALOX5AP P20292 2/20 0.43
PTGES O14684 1/20 0.43
ALOX5 P09917 1/20 0.43
LTC4S Q16873 1/20 0.43
PIK3C2B O00750 3/20 0.42
AGTR1 P30556 6/20 0.40
PPARG P37231 2/20 0.40
CTRC Q99895 1/20 0.39
AGTR2 P50052 3/20 0.39
CCR2 P41597 2/20 0.39
DHODH Q02127 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6496733 0.90 ALOX5AP (0.47) DCTPP1ALOX5APPTGESALOX5LTC4S
SCHEMBL6503273 0.89 CYP1A2 (0.42) AGTR1PPARG
SCHEMBL6172911 0.87 PPARG (0.48) DCTPP1PIK3C2BPPARGCCR2
SCHEMBL7130975 0.87 DCTPP1 (0.51) DCTPP1AGTR1PPARGAGTR2
SCHEMBL6498493 0.86 DCTPP1 (0.40) DCTPP1ALOX5APPTGESALOX5LTC4S
SCHEMBL6491148 0.85 DCTPP1 (0.45) DCTPP1ALOX5APPTGESALOX5LTC4S
SCHEMBL6492577 0.84 DCTPP1 (0.41) DCTPP1ALOX5APPTGESALOX5LTC4S
SCHEMBL6307363 0.84 PPARG (0.51) ALOX5APPTGESALOX5LTC4SAGTR1
SCHEMBL6501198 0.83 NR4A2 (0.48) ALOX5APPPARGDHODH
SCHEMBL6498830 0.83 PIK3C2B (0.41) DCTPP1ALOX5APPTGESALOX5LTC4S

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050014812-A1 Benzimidazole compounds FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2005-01-20 US disclosed
WO-2004108686-A2 BENZIMIDAZOLE COMPOUNDS HAVING HYPOGLYCEMIC ACTIVITY FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2004-12-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050014812-A1 Benzimidazole compounds SLC5A1, SLC5A2, G6PD DCTPP1 1534/4885ALOX5AP 4663/4885PTGES 2082/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.