SCHEMBL7130975

SCHEMBL7130975

Cc1cc(C(=O)O)cc2c1nc(C)n2Cc1ccc(-c2ccccc2)cc1

nearest known ligand 0.51

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
DCTPP1 Q9H773 1/20 0.51
AGTR1 P30556 16/20 0.50
AGTR2 P50052 3/20 0.49
PPARG P37231 2/20 0.47
PDE10A Q9Y233 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6486764 0.87 DCTPP1 (0.44) DCTPP1AGTR1AGTR2PPARG
SCHEMBL7712898 0.83 PDE10A (0.50) DCTPP1PDE10A
SCHEMBL6170384 0.82 HDAC1 (0.57) AGTR1AGTR2PPARG
SCHEMBL16372380 0.81 DCTPP1 (0.51) DCTPP1PPARG
SCHEMBL6496733 0.77 ALOX5AP (0.47) DCTPP1PPARG
SCHEMBL6172911 0.77 PPARG (0.48) DCTPP1PPARG
SCHEMBL6491148 0.76 DCTPP1 (0.45) DCTPP1
SCHEMBL6503273 0.76 CYP1A2 (0.42) AGTR1PPARG
SCHEMBL8266757 0.76 AGTR1 (0.82) AGTR1AGTR2PPARG
SCHEMBL29387259 0.76 AGTR1 (0.82) AGTR1AGTR2PPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004108686-A2 BENZIMIDAZOLE COMPOUNDS HAVING HYPOGLYCEMIC ACTIVITY FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2004-12-16 WO disclosed