Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.59 |
| ▸ | HTR1A | P08908 | 11/20 | 0.57 |
| ▸ | HTR2A | P28223 | 1/20 | 0.57 |
| ▸ | HTR7 | P34969 | 1/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.53 |
| ▸ | DRD3 | P35462 | 2/20 | 0.53 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6475314 | 0.85 | HTR1A (0.62) | DRD2HTR1AADRA1ADRD3ADRA1D | |
| SCHEMBL6482925 | 0.83 | HTR1A (0.69) | DRD2HTR1AADRA1ADRD3ADRA1D | |
| SCHEMBL6482449 | 0.83 | HTR1A (0.65) | DRD2HTR1AADRA1ADRD3ADRA1D | |
| SCHEMBL8651533 | 0.78 | HTR1A (0.57) | DRD2HTR1AHTR7ADRA1ADRD3 | |
| SCHEMBL8643847 | 0.77 | HTR1A (0.51) | DRD2HTR1AHTR7ADRA1ADRD3 | |
| SCHEMBL8646293 | 0.77 | HTR1A (0.53) | DRD2HTR1AHTR2AHTR7ADRA1A | |
| SCHEMBL6547111 | 0.77 | MAPT (0.53) | DRD2HTR1AHTR2AHTR7ADRA1A | |
| SCHEMBL10753828 | 0.77 | IGF1R (0.63) | DRD2HTR1AHTR2AADRA1ADRD3 | |
| Cyclohexane SCHEMBL8646429 | 0.76 | HTR1A (0.54) | DRD2HTR1AHTR2AHTR7ADRA1A | |
| SCHEMBL8646310 | 0.76 | HTR1A (0.52) | DRD2HTR1AHTR7ADRA1ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6894052-B1 | Serotonergic receptor antagonist | RECORDATI S.A. CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 2005-05-17 | — | — | US | disclosed |
| EP-1000046-B1 | PIPERAZINE DERIVATIVES ACTIVE ON THE LOWER URINARY TRACT | RECORDATI CHEM PHARM (CH) | 2003-11-26 | — | — | EP | disclosed |
| EP-1000046-A1 | PIPERAZINE DERIVATIVES ACTIVE ON THE LOWER URINARY TRACT | RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY (CH) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999006383-A1 | PIPERAZINE DERIVATIVES ACTIVE ON THE LOWER URINARY TRACT | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1999-02-11 | — | — | WO | disclosed |